| 13 | Sun Nov 22 | vs Villarreal | 8:00 AM | 4-3-5 | 15 PTS | Spotify Camp Nou · Barcelona, Spain |
| 14 | Sun Nov 29 | at Deportivo | 10:15 AM | 3-6-3 | 15 PTS | Estadio Riazor · A Coruna, Spain |
| 23 | Wed Dec 2 | vs Atletico | 3:30 PM | 9-1-2 | 28 PTS | Spotify Camp Nou · Barcelona, Spain |
| 15 | Sun Dec 6 | vs Celta | 3:00 PM | 2-7-3 | 13 PTS | Spotify Camp Nou · Barcelona, Spain |
| 16 | Sun Dec 13 | at Malaga | 3:00 PM | 0-5-7 | 5 PTS | Estadio La Rosaleda · Malaga, Spain |
| 17 | Sun Dec 20 | vs R. Sociedad | 3:00 PM | 7-1-4 | 22 PTS | Spotify Camp Nou · Barcelona, Spain |
| 18 | Sun Jan 3 | at Espanyol | 3:00 PM | 3-3-6 | 12 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 19 | Sun Jan 10 | at Osasuna | 3:00 PM | 3-3-6 | 12 PTS | Estadio El Sadar · Pamplona, Spain |
| 20 | Sun Jan 17 | vs Elche | 3:00 PM | 2-4-6 | 10 PTS | Spotify Camp Nou · Barcelona, Spain |
| 21 | Sun Jan 24 | at Alaves | 3:00 PM | 3-4-5 | 13 PTS | Mendizorrotza · Vitoria-Gasteiz, Spain |
| 22 | Sun Jan 31 | vs Valencia | 3:00 PM | 2-3-7 | 9 PTS | Spotify Camp Nou · Barcelona, Spain |
| 24 | Sun Feb 14 | at Villarreal | 3:00 PM | 4-3-5 | 15 PTS | Estadio de la Ceramica · Villarreal, Spain |
| 25 | Sun Feb 21 | vs Levante | 3:00 PM | 2-5-5 | 11 PTS | Spotify Camp Nou · Barcelona, Spain |
| 26 | Sun Feb 28 | at Athletic | 3:00 PM | 4-4-3 | 16 PTS | Estadio San Mames · Bilbao, Spain |
| 27 | Sun Mar 7 | vs R. Betis | 3:00 PM | 8-2-2 | 26 PTS | Spotify Camp Nou · Barcelona, Spain |
| 28 | Sun Mar 14 | vs Deportivo | 2:00 PM | 3-6-3 | 15 PTS | Spotify Camp Nou · Barcelona, Spain |
| 29 | Sun Mar 21 | at Rayo | 2:00 PM | 3-3-5 | 12 PTS | Estadio de Vallecas · Madrid, Spain |
| 30 | Sun Apr 4 | vs Sevilla | 2:00 PM | 5-3-4 | 18 PTS | Spotify Camp Nou · Barcelona, Spain |
| 31 | Sun Apr 11 | at Racing | 2:00 PM | 4-2-6 | 14 PTS | Campos de Sport de El Sardinero · Santander, Spain |
| 32 | Sun Apr 18 | vs Espanyol | 2:00 PM | 3-3-6 | 12 PTS | Spotify Camp Nou · Barcelona, Spain |
| 33 | Wed Apr 21 | at Celta | 2:00 PM | 2-7-3 | 13 PTS | Estadio Abanca Balaidos · Vigo, Spain |
| 34 | Sun May 2 | vs Osasuna | 2:00 PM | 3-3-6 | 12 PTS | Spotify Camp Nou · Barcelona, Spain |
| 35 | Sun May 9 | at R. Madrid | 2:00 PM | 10-0-2 | 30 PTS | Estadio Santiago Bernabeu · Madrid, Spain |
| 36 | Sun May 16 | at R. Sociedad | 2:00 PM | 7-1-4 | 22 PTS | Reale Arena · San Sebastian, Spain |
| 37 | Sun May 23 | vs Malaga | 2:00 PM | 0-5-7 | 5 PTS | Spotify Camp Nou · Barcelona, Spain |
| 38 | Sun May 30 | at Getafe | 2:00 PM | 3-3-6 | 12 PTS | Estadio Coliseum · Getafe, Spain |