| 2 | Sun Aug 23 | at Elche | 3:30 PM | 0-0-0 | 0 PTS | Estadio Martinez Valero · Elche, Spain |
| 1 | Thu Aug 27 | vsAthletic | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 3 | Mon Aug 31 | vsRayo | 3:30 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 4 | Sun Sep 6 | atValencia | 10:15 AM | 0-0-0 | 0 PTS | Estadio de Mestalla · Valencia, Spain |
| 5 | Sun Sep 13 | atLevante | 2:00 PM | 0-0-0 | 0 PTS | Estadi Ciutat de Valencia · Valencia, Spain |
| 6 | Wed Sep 16 | vsRacing | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 7 | Sun Sep 20 | atSevilla | 2:00 PM | 0-0-0 | 0 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 8 | Sun Oct 11 | vsGetafe | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 9 | Sun Oct 18 | atR. Betis | 2:00 PM | 0-0-0 | 0 PTS | Estadio de La Cartuja · Sevilla, Spain |
| 10 | Sun Oct 25 | vsR. Madrid | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 11 | Sun Nov 1 | vsAlaves | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 12 | Sun Nov 8 | atAtletico | 3:00 PM | 0-0-0 | 0 PTS | Riyadh Air Metropolitano · Madrid, Spain |
| 13 | Sun Nov 22 | vsVillarreal | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 14 | Sun Nov 29 | atDeportivo | 3:00 PM | 0-0-0 | 0 PTS | Estadio Riazor · A Coruna, Spain |
| 15 | Sun Dec 6 | vsCelta | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 16 | Sun Dec 13 | atMalaga | 3:00 PM | 0-0-0 | 0 PTS | Estadio La Rosaleda · Malaga, Spain |
| 17 | Sun Dec 20 | vsR. Sociedad | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 18 | Sun Jan 3 | atEspanyol | 3:00 PM | 0-0-0 | 0 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 19 | Sun Jan 10 | atOsasuna | 3:00 PM | 0-0-0 | 0 PTS | Estadio El Sadar · Pamplona, Spain |
| 20 | Sun Jan 17 | vsElche | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 21 | Sun Jan 24 | atAlaves | 3:00 PM | 0-0-0 | 0 PTS | Mendizorrotza · Vitoria-Gasteiz, Spain |
| 22 | Sun Jan 31 | vsValencia | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 23 | Sun Feb 7 | vsAtletico | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 24 | Sun Feb 14 | atVillarreal | 3:00 PM | 0-0-0 | 0 PTS | Estadio de la Ceramica · Villarreal, Spain |
| 25 | Sun Feb 21 | vsLevante | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 26 | Sun Feb 28 | atAthletic | 3:00 PM | 0-0-0 | 0 PTS | Estadio San Mames · Bilbao, Spain |
| 27 | Sun Mar 7 | vsR. Betis | 3:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 28 | Sun Mar 14 | vsDeportivo | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 29 | Sun Mar 21 | atRayo | 2:00 PM | 0-0-0 | 0 PTS | Estadio de Vallecas · Madrid, Spain |
| 30 | Sun Apr 4 | vsSevilla | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 31 | Sun Apr 11 | atRacing | 2:00 PM | 0-0-0 | 0 PTS | Campos de Sport de El Sardinero · Santander, Spain |
| 32 | Sun Apr 18 | vsEspanyol | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 33 | Wed Apr 21 | atCelta | 2:00 PM | 0-0-0 | 0 PTS | Estadio Abanca Balaidos · Vigo, Spain |
| 34 | Sun May 2 | vsOsasuna | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 35 | Sun May 9 | atR. Madrid | 2:00 PM | 0-0-0 | 0 PTS | Estadio Santiago Bernabeu · Madrid, Spain |
| 36 | Sun May 16 | atR. Sociedad | 2:00 PM | 0-0-0 | 0 PTS | Reale Arena · San Sebastian, Spain |
| 37 | Sun May 23 | vsMalaga | 2:00 PM | 0-0-0 | 0 PTS | Spotify Camp Nou · Barcelona, Spain |
| 38 | Sun May 30 | atGetafe | 2:00 PM | 0-0-0 | 0 PTS | Estadio Coliseum · Getafe, Spain |
