| 5 | Sat Sep 12 | at Osasuna | 10:15 AM | 2-1-1 | 7 PTS | Estadio El Sadar · Pamplona, Spain |
| 6 | Tue Sep 15 | atRayo | 1:00 PM | 1-1-2 | 4 PTS | Estadio de Vallecas · Madrid, Spain |
| 7 | Fri Sep 18 | vsElche | 3:00 PM | 0-1-3 | 1 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 8 | Fri Oct 9 | atMalaga | 3:00 PM | 0-2-2 | 2 PTS | Estadio La Rosaleda · Malaga, Spain |
| 9 | Sun Oct 18 | vsAtletico | 2:00 PM | 2-1-1 | 7 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 10 | Sun Oct 25 | atRacing | 2:00 PM | 1-1-2 | 4 PTS | Campos de Sport de El Sardinero · Santander, Spain |
| 11 | Sun Nov 1 | atVillarreal | 3:00 PM | 0-2-2 | 2 PTS | Estadio de la Ceramica · Villarreal, Spain |
| 12 | Sun Nov 8 | vsDeportivo | 3:00 PM | 2-2-0 | 8 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 13 | Sun Nov 22 | atAthletic | 3:00 PM | 2-0-2 | 6 PTS | Estadio San Mames · Bilbao, Spain |
| 14 | Sun Nov 29 | vsGetafe | 3:00 PM | 1-1-2 | 4 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 15 | Sun Dec 6 | atAlaves | 3:00 PM | 3-1-0 | 10 PTS | Mendizorrotza · Vitoria-Gasteiz, Spain |
| 16 | Sun Dec 13 | vsCelta | 3:00 PM | 0-3-2 | 3 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 17 | Sun Dec 20 | atValencia | 3:00 PM | 0-1-4 | 1 PTS | Estadio de Mestalla · Valencia, Spain |
| 18 | Sun Jan 3 | vsBarcelona | 3:00 PM | 4-0-0 | 12 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 19 | Sun Jan 10 | vsR. Betis | 3:00 PM | 3-0-1 | 9 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 20 | Sun Jan 17 | atLevante | 3:00 PM | 1-2-1 | 5 PTS | Estadi Ciutat de Valencia · Valencia, Spain |
| 21 | Sun Jan 24 | vsVillarreal | 3:00 PM | 0-2-2 | 2 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 22 | Sun Jan 31 | atAtletico | 3:00 PM | 2-1-1 | 7 PTS | Riyadh Air Metropolitano · Madrid, Spain |
| 23 | Sun Feb 7 | vsRayo | 3:00 PM | 1-1-2 | 4 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 24 | Sun Feb 14 | atSevilla | 3:00 PM | 3-1-1 | 10 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 25 | Sun Feb 21 | vsOsasuna | 3:00 PM | 2-1-1 | 7 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 26 | Sun Feb 28 | atCelta | 3:00 PM | 0-3-2 | 3 PTS | Estadio Abanca Balaidos · Vigo, Spain |
| 27 | Sun Mar 7 | vsRacing | 3:00 PM | 1-1-2 | 4 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 28 | Sun Mar 14 | atR. Madrid | 2:00 PM | 3-0-1 | 9 PTS | Estadio Santiago Bernabeu · Madrid, Spain |
| 29 | Sun Mar 21 | vsAthletic | 2:00 PM | 2-0-2 | 6 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 30 | Sun Apr 4 | atGetafe | 2:00 PM | 1-1-2 | 4 PTS | Estadio Coliseum · Getafe, Spain |
| 31 | Sun Apr 11 | vsMalaga | 2:00 PM | 0-2-2 | 2 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 32 | Sun Apr 18 | atBarcelona | 2:00 PM | 4-0-0 | 12 PTS | Spotify Camp Nou · Barcelona, Spain |
| 33 | Wed Apr 21 | vsR. Sociedad | 2:00 PM | 2-1-2 | 7 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 34 | Sun May 2 | atElche | 2:00 PM | 0-1-3 | 1 PTS | Estadio Martinez Valero · Elche, Spain |
| 35 | Sun May 9 | atR. Betis | 2:00 PM | 3-0-1 | 9 PTS | Estadio de La Cartuja · Sevilla, Spain |
| 36 | Sun May 16 | vsValencia | 2:00 PM | 0-1-4 | 1 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
| 37 | Sun May 23 | atDeportivo | 2:00 PM | 2-2-0 | 8 PTS | Estadio Riazor · A Coruna, Spain |
| 38 | Sun May 30 | vsAlaves | 2:00 PM | 3-1-0 | 10 PTS | RCDE Stadium · Cornella de Llobregat, Spain |
