| 13 | Sat Nov 21 | vs R. Betis | 12:30 PM | 8-2-2 | 26 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 14 | Sun Nov 29 | at R. Sociedad | 3:00 PM | 7-1-4 | 22 PTS | Reale Arena · San Sebastian, Spain |
| 15 | Sun Dec 6 | vs Malaga | 3:00 PM | 0-5-7 | 5 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 16 | Sun Dec 13 | at Elche | 3:00 PM | 2-4-6 | 10 PTS | Estadio Martinez Valero · Elche, Spain |
| 17 | Sun Dec 20 | vs Racing | 3:00 PM | 4-2-6 | 14 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 18 | Sun Jan 3 | at Villarreal | 3:00 PM | 4-3-5 | 15 PTS | Estadio de la Ceramica · Villarreal, Spain |
| 19 | Sun Jan 10 | vs Celta | 3:00 PM | 2-7-3 | 13 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 20 | Sun Jan 17 | at Rayo | 3:00 PM | 3-3-5 | 12 PTS | Estadio de Vallecas · Madrid, Spain |
| 21 | Sun Jan 24 | at Valencia | 3:00 PM | 2-3-7 | 9 PTS | Estadio de Mestalla · Valencia, Spain |
| 22 | Sun Jan 31 | vs Athletic | 3:00 PM | 4-4-3 | 16 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 23 | Sun Feb 7 | at R. Betis | 3:00 PM | 8-2-2 | 26 PTS | Estadio de La Cartuja · Sevilla, Spain |
| 24 | Sun Feb 14 | vs Espanyol | 3:00 PM | 3-3-6 | 12 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 25 | Sun Feb 21 | vs R. Madrid | 3:00 PM | 10-0-2 | 30 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 26 | Sun Feb 28 | at Osasuna | 3:00 PM | 3-3-6 | 12 PTS | Estadio El Sadar · Pamplona, Spain |
| 27 | Sun Mar 7 | vs R. Sociedad | 3:00 PM | 7-1-4 | 22 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 28 | Sun Mar 14 | at Alaves | 2:00 PM | 3-4-5 | 13 PTS | Mendizorrotza · Vitoria-Gasteiz, Spain |
| 29 | Sun Mar 21 | vs Elche | 2:00 PM | 2-4-6 | 10 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 30 | Sun Apr 4 | at Barcelona | 2:00 PM | 11-0-1 | 33 PTS | Spotify Camp Nou · Barcelona, Spain |
| 31 | Sun Apr 11 | vs Deportivo | 2:00 PM | 3-6-3 | 15 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 32 | Sun Apr 18 | at Atletico | 2:00 PM | 9-1-2 | 28 PTS | Riyadh Air Metropolitano · Madrid, Spain |
| 33 | Wed Apr 21 | vs Levante | 2:00 PM | 2-5-5 | 11 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 34 | Sun May 2 | at Celta | 2:00 PM | 2-7-3 | 13 PTS | Estadio Abanca Balaidos · Vigo, Spain |
| 35 | Sun May 9 | at Racing | 2:00 PM | 4-2-6 | 14 PTS | Campos de Sport de El Sardinero · Santander, Spain |
| 36 | Sun May 16 | vs Villarreal | 2:00 PM | 4-3-5 | 15 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 37 | Sun May 23 | vs Getafe | 2:00 PM | 3-3-6 | 12 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 38 | Sun May 30 | at Malaga | 2:00 PM | 0-5-7 | 5 PTS | Estadio La Rosaleda · Malaga, Spain |