| 8 | Sun Oct 11 | vs Celta | 8:00 AM | 0-4-2 | 4 PTS | Estadio Martinez Valero · Elche, Spain |
| 9 | Sat Oct 17 | atVillarreal | 10:15 AM | 0-2-3 | 2 PTS | Estadio de la Ceramica · Villarreal, Spain |
| 10 | Sat Oct 24 | atRayo | 8:00 AM | 2-1-3 | 7 PTS | Estadio de Vallecas · Madrid, Spain |
| 11 | Sun Nov 1 | vsValencia | 3:00 PM | 1-1-4 | 4 PTS | Estadio Martinez Valero · Elche, Spain |
| 12 | Sun Nov 8 | vsR. Betis | 3:00 PM | 4-0-1 | 12 PTS | Estadio Martinez Valero · Elche, Spain |
| 13 | Sun Nov 22 | atLevante | 3:00 PM | 1-2-2 | 5 PTS | Estadi Ciutat de Valencia · Valencia, Spain |
| 14 | Sun Nov 29 | vsAtletico | 3:00 PM | 3-1-1 | 10 PTS | Estadio Martinez Valero · Elche, Spain |
| 15 | Sun Dec 6 | atOsasuna | 3:00 PM | 2-1-2 | 7 PTS | Estadio El Sadar · Pamplona, Spain |
| 16 | Sun Dec 13 | vsSevilla | 3:00 PM | 3-1-1 | 10 PTS | Estadio Martinez Valero · Elche, Spain |
| 17 | Sun Dec 20 | atAlaves | 3:00 PM | 3-1-2 | 10 PTS | Mendizorrotza · Vitoria-Gasteiz, Spain |
| 18 | Sun Jan 3 | atMalaga | 3:00 PM | 0-3-2 | 3 PTS | Estadio La Rosaleda · Malaga, Spain |
| 19 | Sun Jan 10 | vsGetafe | 3:00 PM | 1-2-2 | 5 PTS | Estadio Martinez Valero · Elche, Spain |
| 20 | Sun Jan 17 | atBarcelona | 3:00 PM | 5-0-0 | 15 PTS | Spotify Camp Nou · Barcelona, Spain |
| 21 | Sun Jan 24 | vsRayo | 3:00 PM | 2-1-3 | 7 PTS | Estadio Martinez Valero · Elche, Spain |
| 22 | Sun Jan 31 | atR. Betis | 3:00 PM | 4-0-1 | 12 PTS | Estadio de La Cartuja · Sevilla, Spain |
| 23 | Sun Feb 7 | vsLevante | 3:00 PM | 1-2-2 | 5 PTS | Estadio Martinez Valero · Elche, Spain |
| 24 | Sun Feb 14 | vsDeportivo | 3:00 PM | 2-3-0 | 9 PTS | Estadio Martinez Valero · Elche, Spain |
| 25 | Sun Feb 21 | atAtletico | 3:00 PM | 3-1-1 | 10 PTS | Riyadh Air Metropolitano · Madrid, Spain |
| 26 | Sun Feb 28 | atR. Sociedad | 3:00 PM | 2-1-3 | 7 PTS | Reale Arena · San Sebastian, Spain |
| 27 | Sun Mar 7 | vsMalaga | 3:00 PM | 0-3-2 | 3 PTS | Estadio Martinez Valero · Elche, Spain |
| 28 | Sun Mar 14 | vsVillarreal | 2:00 PM | 0-2-3 | 2 PTS | Estadio Martinez Valero · Elche, Spain |
| 29 | Sun Mar 21 | atSevilla | 2:00 PM | 3-1-1 | 10 PTS | Estadio Ramon Sanchez-Pizjuan · Sevilla, Spain |
| 30 | Sun Apr 4 | vsAlaves | 2:00 PM | 3-1-2 | 10 PTS | Estadio Martinez Valero · Elche, Spain |
| 31 | Sun Apr 11 | atCelta | 2:00 PM | 0-4-2 | 4 PTS | Estadio Abanca Balaidos · Vigo, Spain |
| 32 | Sun Apr 18 | vsOsasuna | 2:00 PM | 2-1-2 | 7 PTS | Estadio Martinez Valero · Elche, Spain |
| 33 | Wed Apr 21 | atR. Madrid | 2:00 PM | 5-0-1 | 15 PTS | Estadio Santiago Bernabeu · Madrid, Spain |
| 34 | Sun May 2 | vsEspanyol | 2:00 PM | 2-1-3 | 7 PTS | Estadio Martinez Valero · Elche, Spain |
| 35 | Sun May 9 | atGetafe | 2:00 PM | 1-2-2 | 5 PTS | Estadio Coliseum · Getafe, Spain |
| 36 | Sun May 16 | vsAthletic | 2:00 PM | 2-1-2 | 7 PTS | Estadio Martinez Valero · Elche, Spain |
| 37 | Sun May 23 | atValencia | 2:00 PM | 1-1-4 | 4 PTS | Estadio de Mestalla · Valencia, Spain |
| 38 | Sun May 30 | vsRacing | 2:00 PM | 2-1-2 | 7 PTS | Estadio Martinez Valero · Elche, Spain |
