Fri November 12, 2021

• FINAL
  

  Niagara

  74
  

  17Ohio State-19½

  84
• FINAL
  

  Radford

  52
  

  25Virginia-17½

  73
• FINAL
  

  Tarleton

  62
  

  3Kansas-26

  88
• FINAL
  

  S Dakota St

  88
  

  14Alabama-12½

  104
• FINAL
  

  Rice

  46
  

  15Houston-13½

  79
• FINAL
  

  UL Monroe

  65
  

  22Auburn-26

  93
• FINAL
  

  Indiana St

  67
  

  7Purdue-26½

  92
• FINAL
  

  Incarnate Word

  60
  

  8Baylor-33½

  87
• FINAL
  

  Arkansas St

  53
  

  11Illinois-16½

  92
• FINAL
  

  Brown

  87
  

  19UNC-24

  94
• FINAL
  

  SMU

  63
  

  13Oregon-7½

  86
• FINAL/OT
  

  4Villanova

  77
  

  2UCLA-3

  86