| 1 | Fri Sep 3 | vs Duke | W31-28 | 1-0 | 1.000 | Jerry Richardson Stadium · Charlotte, NC |
| 2 | Sat Sep 11 | vsGardner-Webb | W38-10 | 2-0 | 1.000 | Jerry Richardson Stadium · Charlotte, NC |
| 3 | Sat Sep 18 | atGeorgia St | L9-20 | 2-1 | .667 | Center Parc Stadium · Atlanta, GA |
| 4 | Fri Sep 24 | vsMTSU | W42-39 | 3-1 | .750 | Jerry Richardson Stadium · Charlotte, NC |
| 5 | Sat Oct 2 | atIllinois | L14-24 | 3-2 | .600 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
| 6 | Fri Oct 8 | atFIU | W45-33 | 4-2 | .667 | Riccardo Silva Stadium · Miami, FL |
| 7 | Thu Oct 21 | vsFAU | L9-38 | 4-3 | .571 | Jerry Richardson Stadium · Charlotte, NC |
| 8 | Sat Oct 30 | atWestern KY | L13-45 | 4-4 | .500 | Houchens Industries-L.T. Smith Stadium · Bowling Green, KY |
| 9 | Sat Nov 6 | vsRice | W31-24 (OT) | 5-4 | .556 | Jerry Richardson Stadium · Charlotte, NC |
| 10 | Sat Nov 13 | atLouisiana Tech | L32-42 | 5-5 | .500 | Joe Aillet Stadium · Ruston, LA |
| 11 | Sat Nov 20 | vsMarshall | L28-49 | 5-6 | .455 | Jerry Richardson Stadium · Charlotte, NC |
| 12 | Sat Nov 27 | atOld Dominion | L34-56 | 5-7 | .417 | S.B. Ballard Stadium · Norfolk, VA |
