| 1 | Sat Aug 30 | at Louisiana | W14-12 | 1-0 | 1.000 | Cajun Field · Lafayette, LA |
| 2 | Sat Sep 6 | vsHouston | L9-35 | 1-1 | .500 | Rice Stadium · Houston, TX |
| 3 | Sat Sep 13 | vsPrairie View | W38-17 | 2-1 | .667 | Rice Stadium · Houston, TX |
| 4 | Thu Sep 18 | atCharlotte | W28-17 | 3-1 | .750 | Jerry Richardson Stadium · Charlotte, NC |
| 5 | Sat Sep 27 | atNavy | L13-21 | 3-2 | .600 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 6 | Sat Oct 4 | vsFAU | L21-27 | 3-3 | .500 | Rice Stadium · Houston, TX |
| 7 | Sat Oct 11 | atUTSA | L13-61 | 3-4 | .429 | Alamodome · San Antonio, TX |
| 8 | Sat Oct 25 | vsUConn | W37-34 (2OT) | 4-4 | .500 | Rice Stadium · Houston, TX |
| 9 | Fri Oct 31 | vs#25Memphis | L14-38 | 4-5 | .444 | Rice Stadium · Houston, TX |
| 10 | Sat Nov 8 | vsUAB | W24-17 | 5-5 | .500 | Rice Stadium · Houston, TX |
