| 1 | Sat Aug 31 | at South Alabama | W52-38 | 1-0 | 1.000 | Hancock Whitney Stadium · Mobile, AL |
| 2 | Sat Sep 7 | vs SF Austin | W35-20 | 2-0 | 1.000 | DATCU Stadium · Denton, TX |
| 3 | Sat Sep 14 | at Texas Tech | L21-66 | 2-1 | .667 | Jones AT&T Stadium · Lubbock, TX |
| 4 | Sat Sep 21 | vs Wyoming | W44-17 | 3-1 | .750 | DATCU Stadium · Denton, TX |
| 5 | Sat Sep 28 | vs Tulsa | W52-20 | 4-1 | .800 | DATCU Stadium · Denton, TX |
| 7 | Sat Oct 12 | at FAU | W41-37 | 5-1 | .833 | FAU Stadium · Boca Raton, FL |
| 8 | Sat Oct 19 | at Memphis | L44-52 | 5-2 | .714 | Simmons Bank Liberty Stadium · Memphis, TN |
| 9 | Sat Oct 26 | vs Tulane | L37-45 | 5-3 | .625 | DATCU Stadium · Denton, TX |
| 11 | Sat Nov 9 | vs #25Army | L3-14 | 5-4 | .556 | DATCU Stadium · Denton, TX |
| 12 | Fri Nov 15 | at UTSA | L27-48 | 5-5 | .500 | Alamodome · San Antonio, TX |
| 13 | Sat Nov 23 | vs E Carolina | L28-40 | 5-6 | .455 | DATCU Stadium · Denton, TX |
| 14 | Sat Nov 30 | at Temple | W24-17 | 6-6 | .500 | Lincoln Financial Field · Philadelphia, PA |
| BOWLS | Fri Jan 3 | at Texas St | L28-30 | 6-7 | .462 | Bobcat Stadium (TX) · San Marcos, TX |
