| 1 | Sat Aug 31 | vs FIU | W31-7 | 1-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 2 | Fri Sep 6 | vs W Illinois | W77-3 | 2-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 3 | Sat Sep 14 | at UCLA | W42-13 | 3-0 | 1.000 | Rose Bowl · Pasadena, CA |
| 4 | Sat Sep 21 | vs Charlotte | W52-14 | 4-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 5 | Sat Sep 28 | vs Maryland | W42-28 | 5-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 6 | Sat Oct 5 | at Northwestern | W41-24 | 6-0 | 1.000 | Ryan Field · Evanston, IL |
| 8 | Sat Oct 19 | vs Nebraska | W56-7 | 7-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 9 | Sat Oct 26 | vs Washington | W31-17 | 8-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 10 | Sat Nov 2 | at Michigan St | W47-10 | 9-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 11 | Sat Nov 9 | vs Michigan | W20-15 | 10-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 13 | Sat Nov 23 | at #2Ohio State | L15-38 | 10-1 | .909 | Ohio Stadium · Columbus, OH |
| 14 | Sat Nov 30 | vs Purdue | W66-0 | 11-1 | .917 | Memorial Stadium · Bloomington, IN |
| CFP | Fri Dec 20 | at #7Notre Dame | L17-27 | 11-2 | .846 | Notre Dame Stadium · Notre Dame, IN |
