| 1 | Fri Sep 2 | vs Illinois | W23-20 | 1-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 2 | Sat Sep 10 | vsIdaho | W35-22 | 2-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 3 | Sat Sep 17 | vsWestern KY | W33-30 (OT) | 3-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 4 | Sat Sep 24 | atCincinnati | L24-45 | 3-1 | .750 | Nippert Stadium · Cincinnati, OH |
| 5 | Sat Oct 1 | atNebraska | L21-35 | 3-2 | .600 | Memorial Stadium · Lincoln, NE |
| 6 | Sat Oct 8 | vs#4Michigan | L10-31 | 3-3 | .500 | Memorial Stadium · Bloomington, IN |
| 7 | Sat Oct 15 | vsMaryland | L33-38 | 3-4 | .429 | Memorial Stadium · Bloomington, IN |
| 8 | Sat Oct 22 | atRutgers | L17-24 | 3-5 | .375 | HighPoint.com Stadium · Piscataway, NJ |
| 9 | Sat Nov 5 | vs#15Penn State | L14-45 | 3-6 | .333 | Memorial Stadium · Bloomington, IN |
| 10 | Sat Nov 12 | at#2Ohio State | L14-56 | 3-7 | .300 | Ohio Stadium · Columbus, OH |
| 11 | Sat Nov 19 | atMichigan St | W39-31 (2OT) | 4-7 | .364 | Spartan Stadium · East Lansing, MI |
| 12 | Sat Nov 26 | vsPurdue | L16-30 | 4-8 | .333 | Memorial Stadium · Bloomington, IN |
