| 1 | Sat Aug 31 | at West Virginia | W34-12 | 1-0 | 1.000 | Milan Puskar Stadium · Morgantown, WV |
| 2 | Sat Sep 7 | vs Bowling Green | W34-27 | 2-0 | 1.000 | Beaver Stadium · University Park, PA |
| 4 | Sat Sep 21 | vs Kent State | W56-0 | 3-0 | 1.000 | Beaver Stadium · University Park, PA |
| 5 | Sat Sep 28 | vs #19Illinois | W21-7 | 4-0 | 1.000 | Beaver Stadium · University Park, PA |
| 6 | Sat Oct 5 | vs UCLA | W27-11 | 5-0 | 1.000 | Beaver Stadium · University Park, PA |
| 7 | Sat Oct 12 | at USC | W33-30 (OT) | 6-0 | 1.000 | Los Angeles Memorial Coliseum · Los Angeles, CA |
| 9 | Sat Oct 26 | at Wisconsin | W28-13 | 7-0 | 1.000 | Camp Randall Stadium · Madison, WI |
| 10 | Sat Nov 2 | vs #4Ohio State | L13-20 | 7-1 | .875 | Beaver Stadium · University Park, PA |
| 11 | Sat Nov 9 | vs Washington | W35-6 | 8-1 | .889 | Beaver Stadium · University Park, PA |
| 12 | Sat Nov 16 | at Purdue | W49-10 | 9-1 | .900 | Ross-Ade Stadium · West Lafayette, IN |
| 13 | Sat Nov 23 | at Minnesota | W26-25 | 10-1 | .909 | Huntington Bank Stadium · Minneapolis, MN |
| 14 | Sat Nov 30 | vs Maryland | W44-7 | 11-1 | .917 | Beaver Stadium · University Park, PA |
| 15 | Sat Dec 7 | at #1Oregon | L37-45 | 11-2 | .846 | Autzen Stadium · Eugene, OR |
| CFP | Sat Dec 21 | vs #11SMU | W38-10 | 12-2 | .857 | Beaver Stadium · University Park, PA |
| CFP | Tue Dec 31 | at #3Boise St | W31-14 | 13-2 | .867 | Albertsons Stadium · Boise, ID |
| CFP | Thu Jan 9 | vs #7Notre Dame | L24-27 | 13-3 | .813 | Beaver Stadium · University Park, PA |
