| 1 | Thu Aug 29 | vs Lafayette | W30-13 | 1-0 | 1.000 | UB Stadium · Buffalo, NY |
| 2 | Sat Sep 7 | at #9Missouri | L0-38 | 1-1 | .500 | Memorial Stadium/Faurot Field · Columbia, MO |
| 3 | Sat Sep 14 | vs UMass | W34-3 | 2-1 | .667 | UB Stadium · Buffalo, NY |
| 4 | Sat Sep 21 | at #23N Illinois | W23-20 (OT) | 3-1 | .750 | Huskie Stadium · Dekalb, IL |
| 5 | Sat Sep 28 | at UConn | L3-47 | 3-2 | .600 | Pratt & Whitney Stadium · East Hartford, CT |
| 7 | Sat Oct 12 | vs Toledo | W30-15 | 4-2 | .667 | UB Stadium · Buffalo, NY |
| 8 | Sat Oct 19 | vs W Michigan | L41-48 | 4-3 | .571 | UB Stadium · Buffalo, NY |
| 9 | Sat Oct 26 | at Ohio | L16-47 | 4-4 | .500 | Peden Stadium · Athens, OH |
| 10 | Sat Nov 2 | at Akron | W41-30 | 5-4 | .556 | InfoCision Stadium · Akron, OH |
| 12 | Tue Nov 12 | vs Ball State | W51-48 (OT) | 6-4 | .600 | UB Stadium · Buffalo, NY |
| 13 | Wed Nov 20 | at E Michigan | W37-20 | 7-4 | .636 | Rynearson Stadium · Ypsilanti, MI |
| 14 | Tue Nov 26 | vs Kent State | W43-7 | 8-4 | .667 | UB Stadium · Buffalo, NY |
| BOWLS | Sat Jan 4 | at Liberty | W26-7 | 9-4 | .692 | Williams Stadium (VA) · Lynchburg, VA |
