| 1 | Thu Sep 2 | vs TBD | W69-7 | 1-0 | 1.000 | UB Stadium · Buffalo, NY |
| 2 | Sat Sep 11 | atNebraska | L3-28 | 1-1 | .500 | Memorial Stadium · Lincoln, NE |
| 3 | Sat Sep 18 | vs16Coast Car | L25-28 | 1-2 | .333 | UB Stadium · Buffalo, NY |
| 4 | Sat Sep 25 | atOld Dominion | W35-34 | 2-2 | .500 | S.B. Ballard Stadium · Norfolk, VA |
| 5 | Sat Oct 2 | vsW Michigan | L17-24 | 2-3 | .400 | UB Stadium · Buffalo, NY |
| 6 | Sat Oct 9 | atKent State | L38-48 | 2-4 | .333 | Dix Stadium · Kent, OH |
| 7 | Sat Oct 16 | vsOhio | W27-26 | 3-4 | .429 | UB Stadium · Buffalo, NY |
| 8 | Sat Oct 23 | atAkron | W45-10 | 4-4 | .500 | InfoCision Stadium · Akron, OH |
| 9 | Sat Oct 30 | vsBowling Green | L44-56 | 4-5 | .444 | UB Stadium · Buffalo, NY |
| 10 | Tue Nov 9 | atMiami OH | L18-45 | 4-6 | .400 | Yager Stadium · Oxford, OH |
| 11 | Wed Nov 17 | vsN Illinois | L27-33 (OT) | 4-7 | .364 | UB Stadium · Buffalo, NY |
| 12 | Tue Nov 23 | atBall State | L3-20 | 4-8 | .333 | Scheumann Stadium · Muncie, IN |
