| 1 | Thu Sep 1 | at Purdue | W35-31 | 1-0 | 1.000 | Ross-Ade Stadium · West Lafayette, IN |
| 2 | Sat Sep 10 | vsOhio | W46-10 | 2-0 | 1.000 | Beaver Stadium · University Park, PA |
| 3 | Sat Sep 17 | atAuburn | W41-12 | 3-0 | 1.000 | Jordan-Hare Stadium · Auburn, AL |
| 4 | Sat Sep 24 | vsC Michigan | W33-14 | 4-0 | 1.000 | Beaver Stadium · University Park, PA |
| 5 | Sat Oct 1 | vsNorthwestern | W17-7 | 5-0 | 1.000 | Beaver Stadium · University Park, PA |
| 6 | Sat Oct 15 | at#5Michigan | L17-41 | 5-1 | .833 | Michigan Stadium · Ann Arbor, MI |
| 7 | Sat Oct 22 | vsMinnesota | W45-17 | 6-1 | .857 | Beaver Stadium · University Park, PA |
| 8 | Sat Oct 29 | vs#2Ohio State | L31-44 | 6-2 | .750 | Beaver Stadium · University Park, PA |
| 9 | Sat Nov 5 | atIndiana | W45-14 | 7-2 | .778 | Memorial Stadium · Bloomington, IN |
| 10 | Sat Nov 12 | vsMaryland | W30-0 | 8-2 | .800 | Beaver Stadium · University Park, PA |
| 11 | Sat Nov 19 | atRutgers | W55-10 | 9-2 | .818 | HighPoint.com Stadium · Piscataway, NJ |
| 12 | Sat Nov 26 | vsMichigan St | W35-16 | 10-2 | .833 | Beaver Stadium · University Park, PA |
| BOWLS | Mon Jan 2 | at#8Utah | W35-21 | 11-2 | .846 | Rice-Eccles Stadium · Salt Lake City, UT |
