| 1 | Sat Aug 30 | vs New Mexico | W34-17 | 1-0 | 1.000 | Michigan Stadium · Ann Arbor, MI |
| 2 | Sat Sep 6 | at#18Oklahoma | L13-24 | 1-1 | .500 | Memorial Stadium · Norman, OK |
| 3 | Sat Sep 13 | vsC Michigan | W63-3 | 2-1 | .667 | Michigan Stadium · Ann Arbor, MI |
| 4 | Sat Sep 20 | atNebraska | W30-27 | 3-1 | .750 | Memorial Stadium · Lincoln, NE |
| 5 | Sat Oct 4 | vsWisconsin | W24-10 | 4-1 | .800 | Michigan Stadium · Ann Arbor, MI |
| 6 | Sat Oct 11 | atUSC | L13-31 | 4-2 | .667 | Los Angeles Memorial Coliseum · Los Angeles, CA |
| 7 | Sat Oct 18 | vsWashington | W24-7 | 5-2 | .714 | Michigan Stadium · Ann Arbor, MI |
| 8 | Sat Oct 25 | atMichigan St | W31-20 | 6-2 | .750 | Spartan Stadium · East Lansing, MI |
| 9 | Sat Nov 1 | vsPurdue | W21-16 | 7-2 | .778 | Michigan Stadium · Ann Arbor, MI |
| 10 | Sat Nov 15 | atNorthwestern | W24-22 | 8-2 | .800 | Ryan Field · Evanston, IL |
| 11 | Sat Nov 22 | atMaryland | W45-20 | 9-2 | .818 | SECU Stadium · College Park, MD |
| 12 | Sat Nov 29 | vs#1Ohio State | L9-27 | 9-3 | .750 | Michigan Stadium · Ann Arbor, MI |
