| 1 | Sat Aug 31 | vs MTSU | W40-21 | 1-0 | 1.000 | Michigan Stadium · Ann Arbor, MI |
| 2 | Sat Sep 7 | vsArmy | W24-21 (2OT) | 2-0 | 1.000 | Michigan Stadium · Ann Arbor, MI |
| 3 | Sat Sep 21 | at#13Wisconsin | L14-35 | 2-1 | .667 | Camp Randall Stadium · Madison, WI |
| 4 | Sat Sep 28 | vsRutgers | W52-0 | 3-1 | .750 | Michigan Stadium · Ann Arbor, MI |
| 5 | Sat Oct 5 | vs#14Iowa | W10-3 | 4-1 | .800 | Michigan Stadium · Ann Arbor, MI |
| 6 | Sat Oct 12 | atIllinois | W42-25 | 5-1 | .833 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
| 7 | Sat Oct 19 | at#7Penn State | L21-28 | 5-2 | .714 | Beaver Stadium · University Park, PA |
| 8 | Sat Oct 26 | vs#8Notre Dame | W45-14 | 6-2 | .750 | Michigan Stadium · Ann Arbor, MI |
| 9 | Sat Nov 2 | atMaryland | W38-7 | 7-2 | .778 | SECU Stadium · College Park, MD |
| 10 | Sat Nov 16 | vsMichigan St | W44-10 | 8-2 | .800 | Michigan Stadium · Ann Arbor, MI |
| 11 | Sat Nov 23 | atIndiana | W39-14 | 9-2 | .818 | Memorial Stadium · Bloomington, IN |
| 12 | Sat Nov 30 | vs#1Ohio State | L27-56 | 9-3 | .750 | Michigan Stadium · Ann Arbor, MI |
| BOWLS | Wed Jan 1 | at#13Alabama | L16-35 | 9-4 | .692 | Bryant-Denny Stadium · Tuscaloosa, AL |
