| 1 | Fri Aug 30 | vs FAU | W16-10 | 1-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 2 | Sat Sep 7 | at Maryland | W27-24 | 2-0 | 1.000 | SECU Stadium · College Park, MD |
| 3 | Sat Sep 14 | vs Prairie View | W40-0 | 3-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 4 | Sat Sep 21 | at Boston College | L19-23 | 3-1 | .750 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 5 | Sat Sep 28 | vs #3Ohio State | L7-38 | 3-2 | .600 | Spartan Stadium · East Lansing, MI |
| 6 | Fri Oct 4 | at #6Oregon | L10-31 | 3-3 | .500 | Autzen Stadium · Eugene, OR |
| 8 | Sat Oct 19 | vs Iowa | W32-20 | 4-3 | .571 | Spartan Stadium · East Lansing, MI |
| 9 | Sat Oct 26 | at Michigan | L17-24 | 4-4 | .500 | Michigan Stadium · Ann Arbor, MI |
| 10 | Sat Nov 2 | vs #13Indiana | L10-47 | 4-5 | .444 | Spartan Stadium · East Lansing, MI |
| 12 | Sat Nov 16 | at Illinois | L16-38 | 4-6 | .400 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
| 13 | Fri Nov 22 | vs Purdue | W24-17 | 5-6 | .455 | Spartan Stadium · East Lansing, MI |
| 14 | Sat Nov 30 | vs Rutgers | L14-41 | 5-7 | .417 | Spartan Stadium · East Lansing, MI |
