| 1 | Fri Aug 30 | vs Tulsa | W28-7 | 1-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 2 | Sat Sep 7 | vsW Michigan | W51-17 | 2-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 3 | Sat Sep 14 | vsArizona St | L7-10 | 2-1 | .667 | Spartan Stadium · East Lansing, MI |
| 4 | Sat Sep 21 | atNorthwestern | W31-10 | 3-1 | .750 | Ryan Field · Evanston, IL |
| 5 | Sat Sep 28 | vsIndiana | W40-31 | 4-1 | .800 | Spartan Stadium · East Lansing, MI |
| 6 | Sat Oct 5 | at#4Ohio State | L10-34 | 4-2 | .667 | Ohio Stadium · Columbus, OH |
| 7 | Sat Oct 12 | at#8Wisconsin | L0-38 | 4-3 | .571 | Camp Randall Stadium · Madison, WI |
| 8 | Sat Oct 26 | vs#6Penn State | L7-28 | 4-4 | .500 | Spartan Stadium · East Lansing, MI |
| 9 | Sat Nov 9 | vsIllinois | L34-37 | 4-5 | .444 | Spartan Stadium · East Lansing, MI |
| 10 | Sat Nov 16 | at#15Michigan | L10-44 | 4-6 | .400 | Michigan Stadium · Ann Arbor, MI |
| 11 | Sat Nov 23 | atRutgers | W27-0 | 5-6 | .455 | HighPoint.com Stadium · Piscataway, NJ |
| 12 | Sat Nov 30 | vsMaryland | W19-16 | 6-6 | .500 | Spartan Stadium · East Lansing, MI |
| BOWLS | Fri Dec 27 | atWake Forest | W27-21 | 7-6 | .538 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
