| 1 | Fri Sep 1 | vs C Michigan | W31-7 | 1-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 2 | Sat Sep 9 | vsRichmond | W45-14 | 2-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 3 | Sat Sep 16 | vs#8Washington | L7-41 | 2-1 | .667 | Spartan Stadium · East Lansing, MI |
| 4 | Sat Sep 23 | vsMaryland | L9-31 | 2-2 | .500 | Spartan Stadium · East Lansing, MI |
| 5 | Sat Sep 30 | atIowa | L16-26 | 2-3 | .400 | Kinnick Stadium · Iowa City, IA |
| 6 | Sat Oct 14 | atRutgers | L24-27 | 2-4 | .333 | HighPoint.com Stadium · Piscataway, NJ |
| 7 | Sat Oct 21 | vs#2Michigan | L0-49 | 2-5 | .286 | Spartan Stadium · East Lansing, MI |
| 8 | Sat Oct 28 | atMinnesota | L12-27 | 2-6 | .250 | Huntington Bank Stadium · Minneapolis, MN |
| 9 | Sat Nov 4 | vsNebraska | W20-17 | 3-6 | .333 | Spartan Stadium · East Lansing, MI |
| 10 | Sat Nov 11 | at#1Ohio State | L3-38 | 3-7 | .300 | Ohio Stadium · Columbus, OH |
| 11 | Sat Nov 18 | atIndiana | W24-21 | 4-7 | .364 | Memorial Stadium · Bloomington, IN |
| 12 | Fri Nov 24 | vs#11Penn State | L0-42 | 4-8 | .333 | Spartan Stadium · East Lansing, MI |
