| 1 | Sat Aug 31 | vs Akron | W52-6 | 1-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 2 | Sat Sep 7 | vs W Michigan | W56-0 | 2-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 4 | Sat Sep 21 | vs Marshall | W49-14 | 3-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 5 | Sat Sep 28 | at Michigan St | W38-7 | 4-0 | 1.000 | Spartan Stadium · East Lansing, MI |
| 6 | Sat Oct 5 | vs Iowa | W35-7 | 5-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 7 | Sat Oct 12 | at #3Oregon | L31-32 | 5-1 | .833 | Autzen Stadium · Eugene, OR |
| 9 | Sat Oct 26 | vs Nebraska | W21-17 | 6-1 | .857 | Ohio Stadium · Columbus, OH |
| 10 | Sat Nov 2 | at #3Penn State | W20-13 | 7-1 | .875 | Beaver Stadium · University Park, PA |
| 11 | Sat Nov 9 | vs Purdue | W45-0 | 8-1 | .889 | Ohio Stadium · Columbus, OH |
| 12 | Sat Nov 16 | at Northwestern | W31-7 | 9-1 | .900 | Ryan Field · Evanston, IL |
| 13 | Sat Nov 23 | vs #5Indiana | W38-15 | 10-1 | .909 | Ohio Stadium · Columbus, OH |
| 14 | Sat Nov 30 | vs Michigan | L10-13 | 10-2 | .833 | Ohio Stadium · Columbus, OH |
| CFP | Sat Dec 21 | vs #9Tennessee | W42-17 | 11-2 | .846 | Ohio Stadium · Columbus, OH |
| CFP | Wed Jan 1 | at#1Oregon | W41-21 | 12-2 | .857 | Autzen Stadium · Eugene, OR |
| CFP | Fri Jan 10 | at #5Texas | W28-14 | 13-2 | .867 | DKR-Texas Memorial Stadium · Austin, TX |
| CFP | Mon Jan 20 | at #7Notre Dame | W34-23 | 14-2 | .875 | Notre Dame Stadium · Notre Dame, IN |
