| 1 | Thu Sep 2 | at Minnesota | W45-31 | 1-0 | 1.000 | Huntington Bank Stadium · Minneapolis, MN |
| 2 | Sat Sep 11 | vs#12Oregon | L28-35 | 1-1 | .500 | Ohio Stadium · Columbus, OH |
| 3 | Sat Sep 18 | vsTulsa | W41-20 | 2-1 | .667 | Ohio Stadium · Columbus, OH |
| 4 | Sat Sep 25 | vsAkron | W59-7 | 3-1 | .750 | Ohio Stadium · Columbus, OH |
| 5 | Sat Oct 2 | atRutgers | W52-13 | 4-1 | .800 | HighPoint.com Stadium · Piscataway, NJ |
| 6 | Sat Oct 9 | vsMaryland | W66-17 | 5-1 | .833 | Ohio Stadium · Columbus, OH |
| 7 | Sat Oct 23 | atIndiana | W54-7 | 6-1 | .857 | Memorial Stadium · Bloomington, IN |
| 8 | Sat Oct 30 | vs#20Penn State | W33-24 | 7-1 | .875 | Ohio Stadium · Columbus, OH |
| 9 | Sat Nov 6 | atNebraska | W26-17 | 8-1 | .889 | Memorial Stadium · Lincoln, NE |
| 10 | Sat Nov 13 | vs#19Purdue | W59-31 | 9-1 | .900 | Ohio Stadium · Columbus, OH |
| 11 | Sat Nov 20 | vs#7Michigan St | W56-7 | 10-1 | .909 | Ohio Stadium · Columbus, OH |
| 12 | Sat Nov 27 | at#5Michigan | L27-42 | 10-2 | .833 | Michigan Stadium · Ann Arbor, MI |
| BOWLS | Sat Jan 1 | vs#11Utah | W48-45 | 11-2 | .846 | Ohio Stadium · Columbus, OH |
