| 1 | Sat Aug 31 | vs FAU | W45-21 | 1-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 2 | Sat Sep 7 | vsCincinnati | W42-0 | 2-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 3 | Sat Sep 14 | atIndiana | W51-10 | 3-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 4 | Sat Sep 21 | vsMiami OH | W76-5 | 4-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 5 | Sat Sep 28 | atNebraska | W48-7 | 5-0 | 1.000 | Memorial Stadium · Lincoln, NE |
| 6 | Sat Oct 5 | vs#25Michigan St | W34-10 | 6-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 7 | Fri Oct 18 | atNorthwestern | W52-3 | 7-0 | 1.000 | Ryan Field · Evanston, IL |
| 8 | Sat Oct 26 | vs#13Wisconsin | W38-7 | 8-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 9 | Sat Nov 9 | vsMaryland | W73-14 | 9-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 10 | Sat Nov 16 | atRutgers | W56-21 | 10-0 | 1.000 | HighPoint.com Stadium · Piscataway, NJ |
| 11 | Sat Nov 23 | vs#8Penn State | W28-17 | 11-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 12 | Sat Nov 30 | at#13Michigan | W56-27 | 12-0 | 1.000 | Michigan Stadium · Ann Arbor, MI |
| 13 | Sat Dec 7 | at#8Wisconsin | W34-21 | 13-0 | 1.000 | Camp Randall Stadium · Madison, WI |
| BOWLS | Sat Dec 28 | vs#3Clemson | L23-29 | 13-1 | .929 | Ohio Stadium · Columbus, OH |
