| 1 | Sat Aug 31 | vs Towson | W38-20 | 1-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 2 | Sat Sep 7 | vs Pitt | L27-28 | 1-1 | .500 | Nippert Stadium · Cincinnati, OH |
| 3 | Sat Sep 14 | at Miami OH | W27-16 | 2-1 | .667 | Yager Stadium · Oxford, OH |
| 4 | Sat Sep 21 | vs Houston | W34-0 | 3-1 | .750 | Nippert Stadium · Cincinnati, OH |
| 5 | Sat Sep 28 | at Texas Tech | L41-44 | 3-2 | .600 | Jones AT&T Stadium · Lubbock, TX |
| 7 | Sat Oct 12 | at UCF | W19-13 | 4-2 | .667 | FBC Mortgage Stadium · Orlando, FL |
| 8 | Sat Oct 19 | vs Arizona St | W24-14 | 5-2 | .714 | Nippert Stadium · Cincinnati, OH |
| 9 | Sat Oct 26 | at Colorado | L23-34 | 5-3 | .625 | Folsom Field · Boulder, CO |
| 11 | Sat Nov 9 | vs West Virginia | L24-31 | 5-4 | .556 | Nippert Stadium · Cincinnati, OH |
| 12 | Sat Nov 16 | at Iowa State | L17-34 | 5-5 | .500 | Jack Trice Stadium · Ames, IA |
| 13 | Sat Nov 23 | at Kansas St | L15-41 | 5-6 | .455 | Bill Snyder Family Stadium · Manhattan, KS |
| 14 | Sat Nov 30 | vs TCU | L13-20 | 5-7 | .417 | Nippert Stadium · Cincinnati, OH |
