| 1 | Thu Aug 28 | vs Nebraska | L17-20 | 0-1 | .000 | Nippert Stadium · Cincinnati, OH |
| 2 | Sat Sep 6 | vsBowling Green | W34-20 | 1-1 | .500 | Nippert Stadium · Cincinnati, OH |
| 3 | Sat Sep 13 | vsN'Western St | W70-0 | 2-1 | .667 | Nippert Stadium · Cincinnati, OH |
| 4 | Sat Sep 27 | atKansas | W37-34 | 3-1 | .750 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 5 | Sat Oct 4 | vs#14Iowa State | W38-30 | 4-1 | .800 | Nippert Stadium · Cincinnati, OH |
| 6 | Sat Oct 11 | vsUCF | W20-11 | 5-1 | .833 | Nippert Stadium · Cincinnati, OH |
| 7 | Sat Oct 18 | atOklahoma St | W49-17 | 6-1 | .857 | Boone Pickens Stadium · Stillwater, OK |
| 8 | Sat Oct 25 | vsBaylor | W41-20 | 7-1 | .875 | Nippert Stadium · Cincinnati, OH |
| 9 | Sat Nov 1 | at#24Utah | L14-45 | 7-2 | .778 | Rice-Eccles Stadium · Salt Lake City, UT |
| 10 | Sat Nov 15 | vsArizona | L24-30 | 7-3 | .700 | Nippert Stadium · Cincinnati, OH |
| 11 | Sat Nov 22 | vs#11BYU | L14-26 | 7-4 | .636 | Nippert Stadium · Cincinnati, OH |
| 12 | Sat Nov 29 | atTCU | L23-45 | 7-5 | .583 | Amon G. Carter Stadium · Fort Worth, TX |
