| 1 | Thu Aug 29 | vs UCLA | W24-14 | 1-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 2 | Sat Sep 7 | at#5Ohio State | L0-42 | 1-1 | .500 | Ohio Stadium · Columbus, OH |
| 3 | Sat Sep 14 | vsMiami OH | W35-13 | 2-1 | .667 | Nippert Stadium · Cincinnati, OH |
| 4 | Sat Sep 28 | atMarshall | W52-14 | 3-1 | .750 | Joan C. Edwards Stadium · Huntington, WV |
| 5 | Fri Oct 4 | vs#18UCF | W27-24 | 4-1 | .800 | Nippert Stadium · Cincinnati, OH |
| 6 | Sat Oct 12 | atHouston | W38-23 | 5-1 | .833 | Robertson Stadium · Houston, TX |
| 7 | Sat Oct 19 | vsTulsa | W24-13 | 6-1 | .857 | Nippert Stadium · Cincinnati, OH |
| 8 | Sat Nov 2 | atE Carolina | W46-43 | 7-1 | .875 | Dowdy-Ficklen Stadium · Greenville, NC |
| 9 | Sat Nov 9 | vsUConn | W48-3 | 8-1 | .889 | Nippert Stadium · Cincinnati, OH |
| 10 | Sat Nov 16 | atSouth Florida | W20-17 | 9-1 | .900 | Raymond James Stadium · Tampa, FL |
| 11 | Sat Nov 23 | vsTemple | W15-13 | 10-1 | .909 | Nippert Stadium · Cincinnati, OH |
| 12 | Fri Nov 29 | at#18Memphis | L24-34 | 10-2 | .833 | Simmons Bank Liberty Stadium · Memphis, TN |
| 13 | Sat Dec 7 | at#17Memphis | L24-29 | 10-3 | .769 | Simmons Bank Liberty Stadium · Memphis, TN |
| BOWLS | Thu Jan 2 | vsBoston College | W38-6 | 11-3 | .786 | Nippert Stadium · Cincinnati, OH |
