| 1 | Sat Aug 31 | vs North Alabama | W40-0 | 1-0 | 1.000 | Simmons Bank Liberty Stadium · Memphis, TN |
| 2 | Sat Sep 7 | vs Troy | W38-17 | 2-0 | 1.000 | Simmons Bank Liberty Stadium · Memphis, TN |
| 3 | Sat Sep 14 | at Florida St | W20-12 | 3-0 | 1.000 | Doak Campbell Stadium · Tallahassee, FL |
| 4 | Sat Sep 21 | at Navy | L44-56 | 3-1 | .750 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 5 | Sat Sep 28 | vs MTSU | W24-7 | 4-1 | .800 | Simmons Bank Liberty Stadium · Memphis, TN |
| 7 | Sat Oct 12 | at South Florida | W21-3 | 5-1 | .833 | Raymond James Stadium · Tampa, FL |
| 8 | Sat Oct 19 | vs North Texas | W52-44 | 6-1 | .857 | Simmons Bank Liberty Stadium · Memphis, TN |
| 9 | Sat Oct 26 | vs Charlotte | W33-28 | 7-1 | .875 | Simmons Bank Liberty Stadium · Memphis, TN |
| 10 | Sat Nov 2 | at UTSA | L36-44 | 7-2 | .778 | Alamodome · San Antonio, TX |
| 11 | Fri Nov 8 | vs Rice | W27-20 | 8-2 | .800 | Simmons Bank Liberty Stadium · Memphis, TN |
| 12 | Sat Nov 16 | vs UAB | W53-18 | 9-2 | .818 | Simmons Bank Liberty Stadium · Memphis, TN |
| 14 | Thu Nov 28 | at #17Tulane | W34-24 | 10-2 | .833 | Yulman Stadium · New Orleans, LA |
| BOWLS | Tue Dec 17 | at West Virginia | W42-37 | 11-2 | .846 | Milan Puskar Stadium · Morgantown, WV |
