| 1 | Thu Aug 28 | vs #25Boise St | W34-7 | 1-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 2 | Sat Sep 6 | at#13Florida | W18-16 | 2-0 | 1.000 | Ben Hill Griffin Stadium · Gainesville, FL |
| 3 | Sat Sep 13 | at#5Miami | L12-49 | 2-1 | .667 | Hard Rock Stadium · Miami Gardens, FL |
| 4 | Sat Sep 20 | vsSC State | W63-14 | 3-1 | .750 | Raymond James Stadium · Tampa, FL |
| 5 | Fri Oct 3 | vsCharlotte | W54-26 | 4-1 | .800 | Raymond James Stadium · Tampa, FL |
| 6 | Fri Oct 10 | atNorth Texas | W63-36 | 5-1 | .833 | DATCU Stadium · Denton, TX |
| 7 | Sat Oct 18 | vsFAU | W48-13 | 6-1 | .857 | Raymond James Stadium · Tampa, FL |
| 8 | Sat Oct 25 | atMemphis | L31-34 | 6-2 | .750 | Simmons Bank Liberty Stadium · Memphis, TN |
| 9 | Thu Nov 6 | vsUTSA | W55-23 | 7-2 | .778 | Raymond James Stadium · Tampa, FL |
| 10 | Sat Nov 15 | atNavy | L38-41 | 7-3 | .700 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 11 | Sat Nov 22 | atUAB | W48-18 | 8-3 | .727 | Legion Field (AL) · Birmingham, AL |
| 12 | Sat Nov 29 | vsRice | W52-3 | 9-3 | .750 | Raymond James Stadium · Tampa, FL |
