| 1 | Sat Sep 4 | vs Miami OH | W49-14 | 1-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 2 | Sat Sep 11 | vsMurray St | W42-7 | 2-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 3 | Sat Sep 18 | atIndiana | W38-24 | 3-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 4 | Sat Oct 2 | at#9Notre Dame | W24-13 | 4-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 5 | Fri Oct 8 | vsTemple | W52-3 | 5-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 6 | Sat Oct 16 | vsUCF | W56-21 | 6-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 7 | Sat Oct 23 | atNavy | W27-20 | 7-0 | 1.000 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 8 | Sat Oct 30 | atTulane | W31-12 | 8-0 | 1.000 | Yulman Stadium · New Orleans, LA |
| 9 | Sat Nov 6 | vsTulsa | W28-20 | 9-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 10 | Fri Nov 12 | atSouth Florida | W45-28 | 10-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 11 | Sat Nov 20 | vsSMU | W48-14 | 11-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 12 | Fri Nov 26 | atE Carolina | W35-13 | 12-0 | 1.000 | Dowdy-Ficklen Stadium · Greenville, NC |
| 13 | Sat Dec 4 | vs#21Houston | W35-20 | 13-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| BOWLS | Fri Dec 31 | at#1Alabama | L6-27 | 13-1 | .929 | Bryant-Denny Stadium · Tuscaloosa, AL |
