| 1 | Sat Sep 2 | vs E Kentucky | W66-13 | 1-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 2 | Sat Sep 9 | atPitt | W27-21 | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sat Sep 16 | vsMiami OH | L24-31 (OT) | 2-1 | .667 | Nippert Stadium · Cincinnati, OH |
| 4 | Sat Sep 23 | vs#16Oklahoma | L6-20 | 2-2 | .500 | Nippert Stadium · Cincinnati, OH |
| 5 | Fri Sep 29 | atBYU | L27-35 | 2-3 | .400 | LaVell Edwards Stadium · Provo, UT |
| 6 | Sat Oct 14 | vsIowa State | L10-30 | 2-4 | .333 | Nippert Stadium · Cincinnati, OH |
| 7 | Sat Oct 21 | vsBaylor | L29-32 | 2-5 | .286 | Nippert Stadium · Cincinnati, OH |
| 8 | Sat Oct 28 | atOklahoma St | L13-45 | 2-6 | .250 | Boone Pickens Stadium · Stillwater, OK |
| 9 | Sat Nov 4 | vsUCF | L26-28 | 2-7 | .222 | Nippert Stadium · Cincinnati, OH |
| 10 | Sat Nov 11 | atHouston | W24-14 | 3-7 | .300 | Robertson Stadium · Houston, TX |
| 11 | Sat Nov 18 | atWest Virginia | L21-42 | 3-8 | .273 | Milan Puskar Stadium · Morgantown, WV |
| 12 | Sat Nov 25 | vsKansas | L16-49 | 3-9 | .250 | Nippert Stadium · Cincinnati, OH |
