| 1 | Sat Aug 31 | vs North Dakota | W21-3 | 1-0 | 1.000 | Jack Trice Stadium · Ames, IA |
| 2 | Sat Sep 7 | at #21Iowa | W20-19 | 2-0 | 1.000 | Kinnick Stadium · Iowa City, IA |
| 4 | Sat Sep 21 | vs Arkansas St | W52-7 | 3-0 | 1.000 | Jack Trice Stadium · Ames, IA |
| 5 | Sat Sep 28 | at Houston | W20-0 | 4-0 | 1.000 | Robertson Stadium · Houston, TX |
| 6 | Sat Oct 5 | vs Baylor | W43-21 | 5-0 | 1.000 | Jack Trice Stadium · Ames, IA |
| 7 | Sat Oct 12 | at West Virginia | W28-16 | 6-0 | 1.000 | Milan Puskar Stadium · Morgantown, WV |
| 8 | Sat Oct 19 | vs UCF | W38-35 | 7-0 | 1.000 | Jack Trice Stadium · Ames, IA |
| 10 | Sat Nov 2 | vs Texas Tech | L22-23 | 7-1 | .875 | Jack Trice Stadium · Ames, IA |
| 11 | Sat Nov 9 | at Kansas | L36-45 | 7-2 | .778 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 12 | Sat Nov 16 | vs Cincinnati | W34-17 | 8-2 | .800 | Jack Trice Stadium · Ames, IA |
| 13 | Sat Nov 23 | at Utah | W31-28 | 9-2 | .818 | Rice-Eccles Stadium · Salt Lake City, UT |
| 14 | Sat Nov 30 | vs #24Kansas St | W29-21 | 10-2 | .833 | Jack Trice Stadium · Ames, IA |
| 15 | Sat Dec 7 | at #15Arizona St | L19-45 | 10-3 | .769 | Mountain America Stadium · Tempe, AZ |
| BOWLS | Sat Dec 28 | at #13Miami | W42-41 | 11-3 | .786 | Hard Rock Stadium · Miami Gardens, FL |
