| 1 | Sat Sep 3 | vs SE Missouri St | W42-10 | 1-0 | 1.000 | Jack Trice Stadium · Ames, IA |
| 2 | Sat Sep 10 | atIowa | W10-7 | 2-0 | 1.000 | Kinnick Stadium · Iowa City, IA |
| 3 | Sat Sep 17 | vsOhio | W43-10 | 3-0 | 1.000 | Jack Trice Stadium · Ames, IA |
| 4 | Sat Sep 24 | vs#17Baylor | L24-31 | 3-1 | .750 | Jack Trice Stadium · Ames, IA |
| 5 | Sat Oct 1 | atKansas | L11-14 | 3-2 | .600 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 6 | Sat Oct 8 | vs#20Kansas St | L9-10 | 3-3 | .500 | Jack Trice Stadium · Ames, IA |
| 7 | Sat Oct 15 | at#22Texas | L21-24 | 3-4 | .429 | DKR-Texas Memorial Stadium · Austin, TX |
| 8 | Sat Oct 29 | vsOklahoma | L13-27 | 3-5 | .375 | Jack Trice Stadium · Ames, IA |
| 9 | Sat Nov 5 | vsWest Virginia | W31-14 | 4-5 | .444 | Jack Trice Stadium · Ames, IA |
| 10 | Sat Nov 12 | atOklahoma St | L14-20 | 4-6 | .400 | Boone Pickens Stadium · Stillwater, OK |
| 11 | Sat Nov 19 | vsTexas Tech | L10-14 | 4-7 | .364 | Jack Trice Stadium · Ames, IA |
| 12 | Sat Nov 26 | at#4TCU | L14-62 | 4-8 | .333 | Amon G. Carter Stadium · Fort Worth, TX |
