| 1 | Sat Aug 31 | vs Northern Iowa | W29-26 (3OT) | 1-0 | 1.000 | Jack Trice Stadium · Ames, IA |
| 2 | Sat Sep 14 | vs#19Iowa | L17-18 | 1-1 | .500 | Jack Trice Stadium · Ames, IA |
| 3 | Sat Sep 21 | vsUL Monroe | W72-20 | 2-1 | .667 | Jack Trice Stadium · Ames, IA |
| 4 | Sat Sep 28 | atBaylor | L21-23 | 2-2 | .500 | Floyd Casey Stadium · Waco, TX |
| 5 | Sat Oct 5 | vsTCU | W49-24 | 3-2 | .600 | Jack Trice Stadium · Ames, IA |
| 6 | Sat Oct 12 | atWest Virginia | W38-14 | 4-2 | .667 | Milan Puskar Stadium · Morgantown, WV |
| 7 | Sat Oct 19 | atTexas Tech | W34-24 | 5-2 | .714 | Jones AT&T Stadium · Lubbock, TX |
| 8 | Sat Oct 26 | vsOklahoma St | L27-34 | 5-3 | .625 | Jack Trice Stadium · Ames, IA |
| 9 | Sat Nov 9 | at#9Oklahoma | L41-42 | 5-4 | .556 | Memorial Stadium · Norman, OK |
| 10 | Sat Nov 16 | vs#19Texas | W23-21 | 6-4 | .600 | Jack Trice Stadium · Ames, IA |
| 11 | Sat Nov 23 | vsKansas | W41-31 | 7-4 | .636 | Jack Trice Stadium · Ames, IA |
| 12 | Sat Nov 30 | atKansas St | L17-27 | 7-5 | .583 | Bill Snyder Family Stadium · Manhattan, KS |
| BOWLS | Sat Dec 28 | vs#15Notre Dame | L9-33 | 7-6 | .538 | Jack Trice Stadium · Ames, IA |
