| 1 | Sat Aug 31 | at #20Texas A&M | W23-13 | 1-0 | 1.000 | Kyle Field · College Station, TX |
| 2 | Sat Sep 7 | vs N Illinois | L14-16 | 1-1 | .500 | Notre Dame Stadium · Notre Dame, IN |
| 3 | Sat Sep 14 | at Purdue | W66-7 | 2-1 | .667 | Ross-Ade Stadium · West Lafayette, IN |
| 4 | Sat Sep 21 | vs Miami OH | W28-3 | 3-1 | .750 | Notre Dame Stadium · Notre Dame, IN |
| 5 | Sat Sep 28 | vs #15Louisville | W31-24 | 4-1 | .800 | Notre Dame Stadium · Notre Dame, IN |
| 7 | Sat Oct 12 | vs Stanford | W49-7 | 5-1 | .833 | Notre Dame Stadium · Notre Dame, IN |
| 8 | Sat Oct 19 | at Georgia Tech | W31-13 | 6-1 | .857 | Bobby Dodd Stadium · Atlanta, GA |
| 9 | Sat Oct 26 | at #24Navy | W51-14 | 7-1 | .875 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 11 | Sat Nov 9 | vs Florida St | W52-3 | 8-1 | .889 | Notre Dame Stadium · Notre Dame, IN |
| 12 | Sat Nov 16 | vs Virginia | W35-14 | 9-1 | .900 | Notre Dame Stadium · Notre Dame, IN |
| 13 | Sat Nov 23 | vs #19Army | W49-14 | 10-1 | .909 | Notre Dame Stadium · Notre Dame, IN |
| 14 | Sat Nov 30 | at USC | W49-35 | 11-1 | .917 | Los Angeles Memorial Coliseum · Los Angeles, CA |
| CFP | Fri Dec 20 | vs #10Indiana | W27-17 | 12-1 | .923 | Notre Dame Stadium · Notre Dame, IN |
| CFP | Thu Jan 2 | at #2Georgia | W23-10 | 13-1 | .929 | Sanford Stadium · Athens, GA |
| CFP | Thu Jan 9 | at #6Penn State | W27-24 | 14-1 | .933 | Beaver Stadium · University Park, PA |
| CFP | Mon Jan 20 | vs #8Ohio State | L23-34 | 14-2 | .875 | Notre Dame Stadium · Notre Dame, IN |
