| 1 | Sun Aug 31 | at #10Miami | L24-27 | 0-1 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 2 | Sat Sep 13 | vs#16Texas A&M | L40-41 | 0-2 | .000 | Notre Dame Stadium · Notre Dame, IN |
| 3 | Sat Sep 20 | vsPurdue | W56-30 | 1-2 | .333 | Notre Dame Stadium · Notre Dame, IN |
| 4 | Sat Sep 27 | atArkansas | W56-13 | 2-2 | .500 | Razorback Stadium · Fayetteville, AR |
| 5 | Sat Oct 4 | vsBoise St | W28-7 | 3-2 | .600 | Notre Dame Stadium · Notre Dame, IN |
| 6 | Sat Oct 11 | vsNC State | W36-7 | 4-2 | .667 | Notre Dame Stadium · Notre Dame, IN |
| 7 | Sat Oct 18 | vs#20USC | W34-24 | 5-2 | .714 | Notre Dame Stadium · Notre Dame, IN |
| 8 | Sat Nov 1 | atBoston College | W25-10 | 6-2 | .750 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 9 | Sat Nov 8 | vsNavy | W49-10 | 7-2 | .778 | Notre Dame Stadium · Notre Dame, IN |
| 10 | Sat Nov 15 | at#22Pitt | W37-15 | 8-2 | .800 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sat Nov 22 | vsSyracuse | W70-7 | 9-2 | .818 | Notre Dame Stadium · Notre Dame, IN |
| 12 | Sat Nov 29 | atStanford | W49-20 | 10-2 | .833 | Stanford Stadium · Stanford, CA |
