| 1 | Mon Sep 1 | vs TCU | L14-48 | 0-1 | .000 | Kenan Stadium · Chapel Hill, NC |
| 2 | Sat Sep 6 | atCharlotte | W20-3 | 1-1 | .500 | Jerry Richardson Stadium · Charlotte, NC |
| 3 | Sat Sep 13 | vsRichmond | W41-6 | 2-1 | .667 | Kenan Stadium · Chapel Hill, NC |
| 4 | Sat Sep 20 | atUCF | L9-34 | 2-2 | .500 | FBC Mortgage Stadium · Orlando, FL |
| 5 | Sat Oct 4 | vsClemson | L10-38 | 2-3 | .400 | Kenan Stadium · Chapel Hill, NC |
| 6 | Fri Oct 17 | atCalifornia | L18-21 | 2-4 | .333 | California Memorial Stadium · Berkeley, CA |
| 7 | Sat Oct 25 | vs#16Virginia | L16-17 (OT) | 2-5 | .286 | Kenan Stadium · Chapel Hill, NC |
| 8 | Fri Oct 31 | atSyracuse | W27-10 | 3-5 | .375 | JMA Wireless Dome · Syracuse, NY |
| 9 | Sat Nov 8 | vsStanford | W20-15 | 4-5 | .444 | Kenan Stadium · Chapel Hill, NC |
| 10 | Sat Nov 15 | atWake Forest | L12-28 | 4-6 | .400 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 11 | Sat Nov 22 | vsDuke | L25-32 | 4-7 | .364 | Kenan Stadium · Chapel Hill, NC |
| 12 | Sat Nov 29 | atNC State | L19-42 | 4-8 | .333 | Carter-Finley Stadium · Raleigh, NC |
