| 1 | Sat Aug 31 | vs Ohio | W38-22 | 1-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 2 | Sat Sep 7 | vs #23Georgia Tech | W31-28 | 2-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 4 | Fri Sep 20 | vs Stanford | L24-26 | 2-1 | .667 | JMA Wireless Dome · Syracuse, NY |
| 5 | Sat Sep 28 | vs Holy Cross | W42-14 | 3-1 | .750 | JMA Wireless Dome · Syracuse, NY |
| 6 | Fri Oct 4 | at #25UNLV | W44-41 (OT) | 4-1 | .800 | Sam Boyd Stadium · Las Vegas, NV |
| 7 | Sat Oct 12 | at NC State | W24-17 | 5-1 | .833 | Carter-Finley Stadium · Raleigh, NC |
| 9 | Thu Oct 24 | at #19Pitt | L13-41 | 5-2 | .714 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sat Nov 2 | vs Virginia Tech | W38-31 (OT) | 6-2 | .750 | JMA Wireless Dome · Syracuse, NY |
| 11 | Sat Nov 9 | at Boston College | L31-37 | 6-3 | .667 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 12 | Sat Nov 16 | at California | W33-25 | 7-3 | .700 | California Memorial Stadium · Berkeley, CA |
| 13 | Sat Nov 23 | vs UConn | W31-24 | 8-3 | .727 | JMA Wireless Dome · Syracuse, NY |
| 14 | Sat Nov 30 | vs #6Miami | W42-38 | 9-3 | .750 | JMA Wireless Dome · Syracuse, NY |
| BOWLS | Fri Dec 27 | at Washington St | W52-35 | 10-3 | .769 | Gesa Field · Pullman, WA |
