| 1 | Sat Aug 30 | at #24Tennessee | L26-45 | 0-1 | .000 | Neyland Stadium · Knoxville, TN |
| 2 | Sat Sep 6 | vsUConn | W27-20 (OT) | 1-1 | .500 | JMA Wireless Dome · Syracuse, NY |
| 3 | Fri Sep 12 | vsColgate | W66-24 | 2-1 | .667 | JMA Wireless Dome · Syracuse, NY |
| 4 | Sat Sep 20 | atClemson | W34-21 | 3-1 | .750 | Memorial Stadium · Clemson, SC |
| 5 | Sat Sep 27 | vsDuke | L3-38 | 3-2 | .600 | JMA Wireless Dome · Syracuse, NY |
| 6 | Sat Oct 4 | atSMU | L18-31 | 3-3 | .500 | Gerald J. Ford Stadium · Dallas, TX |
| 7 | Sat Oct 18 | vsPitt | L13-30 | 3-4 | .429 | JMA Wireless Dome · Syracuse, NY |
| 8 | Sat Oct 25 | at#7Georgia Tech | L16-41 | 3-5 | .375 | Bobby Dodd Stadium · Atlanta, GA |
| 9 | Fri Oct 31 | vsUNC | L10-27 | 3-6 | .333 | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Nov 8 | at#18Miami | L10-38 | 3-7 | .300 | Hard Rock Stadium · Miami Gardens, FL |
| 11 | Sat Nov 22 | at#9Notre Dame | L7-70 | 3-8 | .273 | Notre Dame Stadium · Notre Dame, IN |
| 12 | Sat Nov 29 | vsBoston College | L12-34 | 3-9 | .250 | JMA Wireless Dome · Syracuse, NY |
