| 1 | Sat Sep 3 | vs Louisville | W31-7 | 1-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 2 | Sat Sep 10 | atUConn | W48-14 | 2-0 | 1.000 | Pratt & Whitney Stadium · East Hartford, CT |
| 3 | Sat Sep 17 | vsPurdue | W32-29 | 3-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 4 | Fri Sep 23 | vsVirginia | W22-20 | 4-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 5 | Sat Oct 1 | vsWagner | W59-0 | 5-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 6 | Sat Oct 15 | vs#15NC State | W24-9 | 6-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 7 | Sat Oct 22 | at#5Clemson | L21-27 | 6-1 | .857 | Memorial Stadium · Clemson, SC |
| 8 | Sat Oct 29 | vsNotre Dame | L24-41 | 6-2 | .750 | JMA Wireless Dome · Syracuse, NY |
| 9 | Sat Nov 5 | atPitt | L9-19 | 6-3 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sat Nov 12 | vs#23Florida St | L3-38 | 6-4 | .600 | JMA Wireless Dome · Syracuse, NY |
| 11 | Sat Nov 19 | atWake Forest | L35-45 | 6-5 | .545 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 12 | Sat Nov 26 | atBoston College | W32-23 | 7-5 | .583 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| BOWLS | Thu Dec 29 | atMinnesota | L20-28 | 7-6 | .538 | Huntington Bank Stadium · Minneapolis, MN |
