| 1 | Sat Aug 31 | at Liberty | W24-0 | 1-0 | 1.000 | Williams Stadium (VA) · Lynchburg, VA |
| 2 | Sat Sep 7 | atMaryland | L20-63 | 1-1 | .500 | SECU Stadium · College Park, MD |
| 3 | Sat Sep 14 | vs#1Clemson | L6-41 | 1-2 | .333 | JMA Wireless Dome · Syracuse, NY |
| 4 | Sat Sep 21 | vsW Michigan | W52-33 | 2-2 | .500 | JMA Wireless Dome · Syracuse, NY |
| 5 | Sat Sep 28 | vsHoly Cross | W41-3 | 3-2 | .600 | JMA Wireless Dome · Syracuse, NY |
| 6 | Thu Oct 10 | atNC State | L10-16 | 3-3 | .500 | Carter-Finley Stadium · Raleigh, NC |
| 7 | Fri Oct 18 | vsPitt | L20-27 | 3-4 | .429 | JMA Wireless Dome · Syracuse, NY |
| 8 | Sat Oct 26 | atFlorida St | L17-35 | 3-5 | .375 | Doak Campbell Stadium · Tallahassee, FL |
| 9 | Sat Nov 2 | vsBoston College | L27-58 | 3-6 | .333 | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Nov 16 | atDuke | W49-6 | 4-6 | .400 | Wallace Wade Stadium · Durham, NC |
| 11 | Sat Nov 23 | atLouisville | L34-56 | 4-7 | .364 | Cardinal Stadium · Louisville, KY |
| 12 | Sat Nov 30 | vsWake Forest | W39-30 (OT) | 5-7 | .417 | JMA Wireless Dome · Syracuse, NY |
