| 1 | Sun Sep 6 | at 9Ole Miss | 7:30 PM | 0-0 | .000 | Vaught-Hemingway Stadium · Oxford, MS |
| 2 | Fri Sep 11 | vsTBD | 7:00 PM | 0-1 | .000 | Cardinal Stadium · Louisville, KY |
| 3 | Sat Sep 19 | vs19SMU | 3:30 PM | 0-0 | .000 | Cardinal Stadium · Louisville, KY |
| 4 | Sat Sep 26 | vsWake Forest | TBD | 0-0 | .000 | Cardinal Stadium · Louisville, KY |
| 5 | Sat Oct 3 | atNC State | TBD | 0-1 | .000 | Carter-Finley Stadium · Raleigh, NC |
| 6 | Fri Oct 9 | vsFlorida St | 7:00 PM | 0-0 | .000 | Cardinal Stadium · Louisville, KY |
| 7 | Sat Oct 17 | atSyracuse | TBD | 0-0 | .000 | JMA Wireless Dome · Syracuse, NY |
| 8 | Sat Oct 31 | vsStanford | TBD | 0-0 | .000 | Cardinal Stadium · Louisville, KY |
| 9 | Sat Nov 7 | atGeorgia Tech | TBD | 0-0 | .000 | Bobby Dodd Stadium · Atlanta, GA |
| 10 | Sat Nov 14 | atUNC | TBD | 1-0 | 1.000 | Kenan Stadium · Chapel Hill, NC |
| 11 | Sat Nov 21 | vsPitt | TBD | 0-0 | .000 | Cardinal Stadium · Louisville, KY |
| 12 | Sat Nov 28 | atKentucky | TBD | 0-0 | .000 | Kroger Field · Lexington, KY |
