| Sat Sep 21 | vs Georgia Tech | 3:30 PM | 3-1 | .750 | Cardinal Stadium · Louisville, KY |
| Sat Sep 28 | at #17Notre Dame | 3:30 PM | 2-1 | .667 | Notre Dame Stadium · Notre Dame, IN |
| Sat Oct 5 | vs SMU | TBD | 2-1 | .667 | Cardinal Stadium · Louisville, KY |
| Sat Oct 12 | at Virginia | TBD | 2-1 | .667 | Scott Stadium · Charlottesville, VA |
| Sat Oct 19 | vs #8Miami | TBD | 3-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| Fri Oct 25 | at Boston College | 7:30 PM | 2-1 | .667 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| Sat Nov 2 | at #21Clemson | TBD | 1-1 | .500 | Memorial Stadium · Clemson, SC |
| Sat Nov 16 | at Stanford | TBD | 1-1 | .500 | Stanford Stadium · Stanford, CA |
| Sat Nov 23 | vs Pitt | TBD | 3-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| Sat Nov 30 | at Kentucky | TBD | 1-2 | .333 | Kroger Field · Lexington, KY |
J'Ville St
Austin Peay