| Sat Nov 16 | at Stanford | L35-38 | 6-4 | .600 | Stanford Stadium · Stanford, CA |
| Sat Nov 2 | at #11Clemson | W33-21 | 6-3 | .667 | Memorial Stadium · Clemson, SC |
| Fri Oct 25 | at Boston College | W31-27 | 5-3 | .625 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| Sat Oct 19 | vs #6Miami | L45-52 | 4-3 | .571 | Cardinal Stadium · Louisville, KY |
| Sat Oct 12 | at Virginia | W24-20 | 4-2 | .667 | Scott Stadium · Charlottesville, VA |
| Sat Oct 5 | vs SMU | L27-34 | 3-2 | .600 | Cardinal Stadium · Louisville, KY |
| Sat Sep 28 | at #16Notre Dame | L24-31 | 3-1 | .750 | Notre Dame Stadium · Notre Dame, IN |
| Sat Sep 21 | vs Georgia Tech | W31-19 | 3-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| Sat Sep 7 | vs J'Ville St | W49-14 | 2-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| Sat Aug 31 | vs Austin Peay | W62-0 | 1-0 | 1.000 | Cardinal Stadium · Louisville, KY |
