| 1 | Sat Aug 31 | vs Austin Peay | W62-0 | 1-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| 2 | Sat Sep 7 | vs J'Ville St | W49-14 | 2-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| 4 | Sat Sep 21 | vs Georgia Tech | W31-19 | 3-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| 5 | Sat Sep 28 | at #16Notre Dame | L24-31 | 3-1 | .750 | Notre Dame Stadium · Notre Dame, IN |
| 6 | Sat Oct 5 | vs SMU | L27-34 | 3-2 | .600 | Cardinal Stadium · Louisville, KY |
| 7 | Sat Oct 12 | at Virginia | W24-20 | 4-2 | .667 | Scott Stadium · Charlottesville, VA |
| 8 | Sat Oct 19 | vs #6Miami | L45-52 | 4-3 | .571 | Cardinal Stadium · Louisville, KY |
| 9 | Fri Oct 25 | at Boston College | W31-27 | 5-3 | .625 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 10 | Sat Nov 2 | at #11Clemson | W33-21 | 6-3 | .667 | Memorial Stadium · Clemson, SC |
| 12 | Sat Nov 16 | at Stanford | L35-38 | 6-4 | .600 | Stanford Stadium · Stanford, CA |
| 13 | Sat Nov 23 | vs Pitt | W37-9 | 7-4 | .636 | Cardinal Stadium · Louisville, KY |
| 14 | Sat Nov 30 | at Kentucky | W41-14 | 8-4 | .667 | Kroger Field · Lexington, KY |
| BOWLS | Tue Dec 31 | at Washington | W35-34 | 9-4 | .692 | Husky Stadium · Seattle, WA |
