| 1 | Sat Aug 31 | vs Southern Miss | W31-0 | 1-0 | 1.000 | Kroger Field · Lexington, KY |
| 2 | Sat Sep 7 | vs South Carolina | L6-31 | 1-1 | .500 | Kroger Field · Lexington, KY |
| 3 | Sat Sep 14 | vs #1Georgia | L12-13 | 1-2 | .333 | Kroger Field · Lexington, KY |
| 4 | Sat Sep 21 | vs Ohio | W41-6 | 2-2 | .500 | Kroger Field · Lexington, KY |
| 5 | Sat Sep 28 | at #6Ole Miss | W20-17 | 3-2 | .600 | Vaught-Hemingway Stadium · Oxford, MS |
| 7 | Sat Oct 12 | vs Vanderbilt | L13-20 | 3-3 | .500 | Kroger Field · Lexington, KY |
| 8 | Sat Oct 19 | at Florida | L20-48 | 3-4 | .429 | Ben Hill Griffin Stadium · Gainesville, FL |
| 9 | Sat Oct 26 | vs Auburn | L10-24 | 3-5 | .375 | Kroger Field · Lexington, KY |
| 10 | Sat Nov 2 | at #7Tennessee | L18-28 | 3-6 | .333 | Neyland Stadium · Knoxville, TN |
| 12 | Sat Nov 16 | vs Murray St | W48-6 | 4-6 | .400 | Kroger Field · Lexington, KY |
| 13 | Sat Nov 23 | at #3Texas | L14-31 | 4-7 | .364 | DKR-Texas Memorial Stadium · Austin, TX |
| 14 | Sat Nov 30 | vs Louisville | L14-41 | 4-8 | .333 | Kroger Field · Lexington, KY |
