| 1 | Sat Aug 30 | vs Syracuse | W45-26 | 1-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 2 | Sat Sep 6 | vsETSU | W72-17 | 2-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 3 | Sat Sep 13 | vs#6Georgia | L41-44 (OT) | 2-1 | .667 | Neyland Stadium · Knoxville, TN |
| 4 | Sat Sep 20 | vsUAB | W56-24 | 3-1 | .750 | Neyland Stadium · Knoxville, TN |
| 5 | Sat Sep 27 | atMississippi St | W41-34 (OT) | 4-1 | .800 | Davis Wade Stadium · Starkville, MS |
| 6 | Sat Oct 11 | vsArkansas | W34-31 | 5-1 | .833 | Neyland Stadium · Knoxville, TN |
| 7 | Sat Oct 18 | at#6Alabama | L20-37 | 5-2 | .714 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 8 | Sat Oct 25 | atKentucky | W56-34 | 6-2 | .750 | Kroger Field · Lexington, KY |
| 9 | Sat Nov 1 | vs#18Oklahoma | L27-33 | 6-3 | .667 | Neyland Stadium · Knoxville, TN |
| 10 | Sat Nov 15 | vsNew Mexico St | W42-9 | 7-3 | .700 | Neyland Stadium · Knoxville, TN |
| 11 | Sat Nov 22 | atFlorida | W31-11 | 8-3 | .727 | Ben Hill Griffin Stadium · Gainesville, FL |
| 12 | Sat Nov 29 | vs#14Vanderbilt | L24-45 | 8-4 | .667 | Neyland Stadium · Knoxville, TN |
