| 1 | Sat Aug 31 | vs Chattanooga | W69-3 | 1-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 2 | Sat Sep 7 | at #24NC State | W51-10 | 2-0 | 1.000 | Carter-Finley Stadium · Raleigh, NC |
| 3 | Sat Sep 14 | vs Kent State | W71-0 | 3-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 4 | Sat Sep 21 | at #15Oklahoma | W25-15 | 4-0 | 1.000 | Memorial Stadium · Norman, OK |
| 6 | Sat Oct 5 | at Arkansas | L14-19 | 4-1 | .800 | Razorback Stadium · Fayetteville, AR |
| 7 | Sat Oct 12 | vs Florida | W23-17 (OT) | 5-1 | .833 | Neyland Stadium · Knoxville, TN |
| 8 | Sat Oct 19 | vs #7Alabama | W24-17 | 6-1 | .857 | Neyland Stadium · Knoxville, TN |
| 10 | Sat Nov 2 | vs Kentucky | W28-18 | 7-1 | .875 | Neyland Stadium · Knoxville, TN |
| 11 | Sat Nov 9 | vs Mississippi St | W33-14 | 8-1 | .889 | Neyland Stadium · Knoxville, TN |
| 12 | Sat Nov 16 | at #12Georgia | L17-31 | 8-2 | .800 | Sanford Stadium · Athens, GA |
| 13 | Sat Nov 23 | vs UTEP | W56-0 | 9-2 | .818 | Neyland Stadium · Knoxville, TN |
| 14 | Sat Nov 30 | at Vanderbilt | W36-23 | 10-2 | .833 | FirstBank Stadium · Nashville, TN |
| CFP | Sat Dec 21 | at #8Ohio State | L17-42 | 10-3 | .769 | Ohio Stadium · Columbus, OH |
