| 1 | Sat Sep 2 | vs Virginia | W49-13 | 1-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 2 | Sat Sep 9 | vsAustin Peay | W30-13 | 2-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 3 | Sat Sep 16 | atFlorida | L16-29 | 2-1 | .667 | Ben Hill Griffin Stadium · Gainesville, FL |
| 4 | Sat Sep 23 | vsUTSA | W45-14 | 3-1 | .750 | Neyland Stadium · Knoxville, TN |
| 5 | Sat Sep 30 | vsSouth Carolina | W41-20 | 4-1 | .800 | Neyland Stadium · Knoxville, TN |
| 6 | Sat Oct 14 | vsTexas A&M | W20-13 | 5-1 | .833 | Neyland Stadium · Knoxville, TN |
| 7 | Sat Oct 21 | at#11Alabama | L20-34 | 5-2 | .714 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 8 | Sat Oct 28 | atKentucky | W33-27 | 6-2 | .750 | Kroger Field · Lexington, KY |
| 9 | Sat Nov 4 | vsUConn | W59-3 | 7-2 | .778 | Neyland Stadium · Knoxville, TN |
| 10 | Sat Nov 11 | at#14Missouri | L7-36 | 7-3 | .700 | Memorial Stadium/Faurot Field · Columbia, MO |
| 11 | Sat Nov 18 | vs#1Georgia | L10-38 | 7-4 | .636 | Neyland Stadium · Knoxville, TN |
| 12 | Sat Nov 25 | vsVanderbilt | W48-24 | 8-4 | .667 | Neyland Stadium · Knoxville, TN |
| BOWLS | Mon Jan 1 | vs#17Iowa | W35-0 | 9-4 | .692 | Neyland Stadium · Knoxville, TN |
