| 1 | Sat Aug 31 | vs Old Dominion | W23-19 | 1-0 | 1.000 | Williams-Brice Stadium · Columbia, SC |
| 2 | Sat Sep 7 | at Kentucky | W31-6 | 2-0 | 1.000 | Kroger Field · Lexington, KY |
| 3 | Sat Sep 14 | vs #16LSU | L33-36 | 2-1 | .667 | Williams-Brice Stadium · Columbia, SC |
| 4 | Sat Sep 21 | vs Akron | W50-7 | 3-1 | .750 | Williams-Brice Stadium · Columbia, SC |
| 6 | Sat Oct 5 | vs #12Ole Miss | L3-27 | 3-2 | .600 | Williams-Brice Stadium · Columbia, SC |
| 7 | Sat Oct 12 | at #7Alabama | L25-27 | 3-3 | .500 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 8 | Sat Oct 19 | at Oklahoma | W35-9 | 4-3 | .571 | Memorial Stadium · Norman, OK |
| 10 | Sat Nov 2 | vs #10Texas A&M | W44-20 | 5-3 | .625 | Williams-Brice Stadium · Columbia, SC |
| 11 | Sat Nov 9 | at Vanderbilt | W28-7 | 6-3 | .667 | FirstBank Stadium · Nashville, TN |
| 12 | Sat Nov 16 | vs #23Missouri | W34-30 | 7-3 | .700 | Williams-Brice Stadium · Columbia, SC |
| 13 | Sat Nov 23 | vs Wofford | W56-12 | 8-3 | .727 | Williams-Brice Stadium · Columbia, SC |
| 14 | Sat Nov 30 | at #12Clemson | W17-14 | 9-3 | .750 | Memorial Stadium · Clemson, SC |
| BOWLS | Tue Dec 31 | at #20Illinois | L17-21 | 9-4 | .692 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
