| 1 | Sun Aug 31 | vs Virginia Tech | W24-11 | 1-0 | 1.000 | Williams-Brice Stadium · Columbia, SC |
| 2 | Sat Sep 6 | vsSC State | W38-10 | 2-0 | 1.000 | Williams-Brice Stadium · Columbia, SC |
| 3 | Sat Sep 13 | vsVanderbilt | L7-31 | 2-1 | .667 | Williams-Brice Stadium · Columbia, SC |
| 4 | Sat Sep 20 | at#23Missouri | L20-29 | 2-2 | .500 | Memorial Stadium/Faurot Field · Columbia, MO |
| 5 | Sat Sep 27 | vsKentucky | W35-13 | 3-2 | .600 | Williams-Brice Stadium · Columbia, SC |
| 6 | Sat Oct 11 | at#11LSU | L10-20 | 3-3 | .500 | Tiger Stadium · Baton Rouge, LA |
| 7 | Sat Oct 18 | vs#14Oklahoma | L7-26 | 3-4 | .429 | Williams-Brice Stadium · Columbia, SC |
| 8 | Sat Oct 25 | vs#4Alabama | L22-29 | 3-5 | .375 | Williams-Brice Stadium · Columbia, SC |
| 9 | Sat Nov 1 | at#7Ole Miss | L14-30 | 3-6 | .333 | Vaught-Hemingway Stadium · Oxford, MS |
| 10 | Sat Nov 15 | at#3Texas A&M | L30-31 | 3-7 | .300 | Kyle Field · College Station, TX |
| 11 | Sat Nov 22 | vsCoast Car | W51-7 | 4-7 | .364 | Williams-Brice Stadium · Columbia, SC |
| 12 | Sat Nov 29 | vsClemson | L14-28 | 4-8 | .333 | Williams-Brice Stadium · Columbia, SC |
