| 1 | Sat Sep 26 | vs #16Tennessee | L27-31 | 0-1 | .000 | Williams-Brice Stadium · Columbia, SC |
| 2 | Sat Oct 3 | at#3Florida | L24-38 | 0-2 | .000 | Ben Hill Griffin Stadium · Gainesville, FL |
| 3 | Sat Oct 10 | atVanderbilt | W41-7 | 1-2 | .333 | FirstBank Stadium · Nashville, TN |
| 4 | Sat Oct 17 | vs#15Auburn | W30-22 | 2-2 | .500 | Williams-Brice Stadium · Columbia, SC |
| 5 | Sat Oct 24 | atLSU | L24-52 | 2-3 | .400 | Tiger Stadium · Baton Rouge, LA |
| 6 | Sat Nov 7 | vs#7Texas A&M | L3-48 | 2-4 | .333 | Williams-Brice Stadium · Columbia, SC |
| 7 | Sat Nov 14 | atOle Miss | L42-59 | 2-5 | .286 | Vaught-Hemingway Stadium · Oxford, MS |
| 8 | Sat Nov 21 | vsMissouri | L10-17 | 2-6 | .250 | Williams-Brice Stadium · Columbia, SC |
| 9 | Sat Nov 28 | vsGeorgia | L16-45 | 2-7 | .222 | Williams-Brice Stadium · Columbia, SC |
| 10 | Sat Dec 5 | atKentucky | L18-41 | 2-8 | .200 | Kroger Field · Lexington, KY |
