| 1 | Sat Sep 2 | vs #21UNC | L17-31 | 0-1 | .000 | Williams-Brice Stadium · Columbia, SC |
| 2 | Sat Sep 9 | vsFurman | W47-21 | 1-1 | .500 | Williams-Brice Stadium · Columbia, SC |
| 3 | Sat Sep 16 | at#1Georgia | L14-24 | 1-2 | .333 | Sanford Stadium · Athens, GA |
| 4 | Sat Sep 23 | vsMississippi St | W37-30 | 2-2 | .500 | Williams-Brice Stadium · Columbia, SC |
| 5 | Sat Sep 30 | at#21Tennessee | L20-41 | 2-3 | .400 | Neyland Stadium · Knoxville, TN |
| 6 | Sat Oct 14 | vsFlorida | L39-41 | 2-4 | .333 | Williams-Brice Stadium · Columbia, SC |
| 7 | Sat Oct 21 | at#20Missouri | L12-34 | 2-5 | .286 | Memorial Stadium/Faurot Field · Columbia, MO |
| 8 | Sat Oct 28 | atTexas A&M | L17-30 | 2-6 | .250 | Kyle Field · College Station, TX |
| 9 | Sat Nov 4 | vsJ'Ville St | W38-28 | 3-6 | .333 | Williams-Brice Stadium · Columbia, SC |
| 10 | Sat Nov 11 | vsVanderbilt | W47-6 | 4-6 | .400 | Williams-Brice Stadium · Columbia, SC |
| 11 | Sat Nov 18 | vsKentucky | W17-14 | 5-6 | .455 | Williams-Brice Stadium · Columbia, SC |
| 12 | Sat Nov 25 | vs#24Clemson | L7-16 | 5-7 | .417 | Williams-Brice Stadium · Columbia, SC |
