| 1 | Sat Sep 3 | vs Georgia St | W35-14 | 1-0 | 1.000 | Williams-Brice Stadium · Columbia, SC |
| 2 | Sat Sep 10 | at#16Arkansas | L30-44 | 1-1 | .500 | Razorback Stadium · Fayetteville, AR |
| 3 | Sat Sep 17 | vsGeorgia | L7-48 | 1-2 | .333 | Williams-Brice Stadium · Columbia, SC |
| 4 | Sat Sep 24 | vsCharlotte | W56-20 | 2-2 | .500 | Williams-Brice Stadium · Columbia, SC |
| 5 | Thu Sep 29 | vsSC State | W50-10 | 3-2 | .600 | Williams-Brice Stadium · Columbia, SC |
| 6 | Sat Oct 8 | atKentucky | W24-14 | 4-2 | .667 | Kroger Field · Lexington, KY |
| 7 | Sat Oct 22 | vsTexas A&M | W30-24 | 5-2 | .714 | Williams-Brice Stadium · Columbia, SC |
| 8 | Sat Oct 29 | vsMissouri | L10-23 | 5-3 | .625 | Williams-Brice Stadium · Columbia, SC |
| 9 | Sat Nov 5 | atVanderbilt | W38-27 | 6-3 | .667 | FirstBank Stadium · Nashville, TN |
| 10 | Sat Nov 12 | atFlorida | L6-38 | 6-4 | .600 | Ben Hill Griffin Stadium · Gainesville, FL |
| 11 | Sat Nov 19 | vs#5Tennessee | W63-38 | 7-4 | .636 | Williams-Brice Stadium · Columbia, SC |
| 12 | Sat Nov 26 | at#8Clemson | W31-30 | 8-4 | .667 | Memorial Stadium · Clemson, SC |
| BOWLS | Fri Dec 30 | vsNotre Dame | L38-45 | 8-5 | .615 | Williams-Brice Stadium · Columbia, SC |
