| 1 | Sat Aug 31 | at #1Georgia | L3-34 | 0-1 | .000 | Sanford Stadium · Athens, GA |
| 2 | Sat Sep 7 | vs Appalachian St | W66-20 | 1-1 | .500 | Memorial Stadium · Clemson, SC |
| 4 | Sat Sep 21 | vs NC State | W59-35 | 2-1 | .667 | Memorial Stadium · Clemson, SC |
| 5 | Sat Sep 28 | vs Stanford | W40-14 | 3-1 | .750 | Memorial Stadium · Clemson, SC |
| 6 | Sat Oct 5 | at Florida St | W29-13 | 4-1 | .800 | Doak Campbell Stadium · Tallahassee, FL |
| 7 | Sat Oct 12 | at Wake Forest | W49-14 | 5-1 | .833 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 8 | Sat Oct 19 | vs Virginia | W48-31 | 6-1 | .857 | Memorial Stadium · Clemson, SC |
| 10 | Sat Nov 2 | vs Louisville | L21-33 | 6-2 | .750 | Memorial Stadium · Clemson, SC |
| 11 | Sat Nov 9 | at Virginia Tech | W24-14 | 7-2 | .778 | Lane Stadium · Blacksburg, VA |
| 12 | Sat Nov 16 | at Pitt | W24-20 | 8-2 | .800 | Acrisure Stadium · Pittsburgh, PA |
| 13 | Sat Nov 23 | vs The Citadel | W51-14 | 9-2 | .818 | Memorial Stadium · Clemson, SC |
| 14 | Sat Nov 30 | vs #15South Carolina | L14-17 | 9-3 | .750 | Memorial Stadium · Clemson, SC |
| 15 | Sat Dec 7 | at #8SMU | W34-31 | 10-3 | .769 | Gerald J. Ford Stadium · Dallas, TX |
| CFP | Sat Dec 21 | at #5Texas | L24-38 | 10-4 | .714 | DKR-Texas Memorial Stadium · Austin, TX |
