| 1 | Thu Aug 28 | vs Elon | W45-17 | 1-0 | 1.000 | Wallace Wade Stadium · Durham, NC |
| 2 | Sat Sep 6 | vs#11Illinois | L19-45 | 1-1 | .500 | Wallace Wade Stadium · Durham, NC |
| 3 | Sat Sep 13 | atTulane | L27-34 | 1-2 | .333 | Yulman Stadium · New Orleans, LA |
| 4 | Sat Sep 20 | vsNC State | W45-33 | 2-2 | .500 | Wallace Wade Stadium · Durham, NC |
| 5 | Sat Sep 27 | atSyracuse | W38-3 | 3-2 | .600 | JMA Wireless Dome · Syracuse, NY |
| 6 | Sat Oct 4 | atCalifornia | W45-21 | 4-2 | .667 | California Memorial Stadium · Berkeley, CA |
| 7 | Sat Oct 18 | vs#12Georgia Tech | L18-27 | 4-3 | .571 | Wallace Wade Stadium · Durham, NC |
| 8 | Sat Nov 1 | atClemson | W46-45 | 5-3 | .625 | Memorial Stadium · Clemson, SC |
| 9 | Sat Nov 8 | atUConn | L34-37 | 5-4 | .556 | Pratt & Whitney Stadium · East Hartford, CT |
| 10 | Sat Nov 15 | vs#19Virginia | L17-34 | 5-5 | .500 | Wallace Wade Stadium · Durham, NC |
| 11 | Sat Nov 22 | atUNC | W32-25 | 6-5 | .545 | Kenan Stadium · Chapel Hill, NC |
| 12 | Sat Nov 29 | vsWake Forest | W49-32 | 7-5 | .583 | Wallace Wade Stadium · Durham, NC |
