| 1 | Fri Sep 2 | vs Temple | W30-0 | 1-0 | 1.000 | Wallace Wade Stadium · Durham, NC |
| 2 | Sat Sep 10 | atNorthwestern | W31-23 | 2-0 | 1.000 | Ryan Field · Evanston, IL |
| 3 | Sat Sep 17 | vsNC A&T | W49-20 | 3-0 | 1.000 | Wallace Wade Stadium · Durham, NC |
| 4 | Sat Sep 24 | atKansas | L27-35 | 3-1 | .750 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 5 | Sat Oct 1 | vsVirginia | W38-17 | 4-1 | .800 | Wallace Wade Stadium · Durham, NC |
| 6 | Sat Oct 8 | atGeorgia Tech | L20-23 (OT) | 4-2 | .667 | Bobby Dodd Stadium · Atlanta, GA |
| 7 | Sat Oct 15 | vsUNC | L35-38 | 4-3 | .571 | Wallace Wade Stadium · Durham, NC |
| 8 | Sat Oct 22 | atMiami | W45-21 | 5-3 | .625 | Hard Rock Stadium · Miami Gardens, FL |
| 9 | Fri Nov 4 | atBoston College | W38-31 | 6-3 | .667 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 10 | Sat Nov 12 | vsVirginia Tech | W24-7 | 7-3 | .700 | Wallace Wade Stadium · Durham, NC |
| 11 | Sat Nov 19 | atPitt | L26-28 | 7-4 | .636 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sat Nov 26 | vsWake Forest | W34-31 | 8-4 | .667 | Wallace Wade Stadium · Durham, NC |
| BOWLS | Wed Dec 28 | vsUCF | W30-13 | 9-4 | .692 | Wallace Wade Stadium · Durham, NC |
