| 1 | Fri Aug 30 | vs Elon | W26-3 | 1-0 | 1.000 | Wallace Wade Stadium · Durham, NC |
| 2 | Fri Sep 6 | atNorthwestern | W26-20 (2OT) | 2-0 | 1.000 | Ryan Field · Evanston, IL |
| 3 | Sat Sep 14 | vsUConn | W26-21 | 3-0 | 1.000 | Wallace Wade Stadium · Durham, NC |
| 4 | Sat Sep 21 | atMTSU | W45-17 | 4-0 | 1.000 | Johnny "Red" Floyd Stadium · Murfreesboro, TN |
| 5 | Sat Sep 28 | vsUNC | W21-20 | 5-0 | 1.000 | Wallace Wade Stadium · Durham, NC |
| 6 | Sat Oct 5 | atGeorgia Tech | L14-24 | 5-1 | .833 | Bobby Dodd Stadium · Atlanta, GA |
| 7 | Fri Oct 18 | vsFlorida St | W23-16 | 6-1 | .857 | Wallace Wade Stadium · Durham, NC |
| 8 | Sat Oct 26 | vs#22SMU | L27-28 (OT) | 6-2 | .750 | Wallace Wade Stadium · Durham, NC |
| 9 | Sat Nov 2 | at#5Miami | L31-53 | 6-3 | .667 | Hard Rock Stadium · Miami Gardens, FL |
| 10 | Sat Nov 9 | atNC State | W29-19 | 7-3 | .700 | Carter-Finley Stadium · Raleigh, NC |
| 11 | Sat Nov 23 | vsVirginia Tech | W31-28 | 8-3 | .727 | Wallace Wade Stadium · Durham, NC |
| 12 | Sat Nov 30 | atWake Forest | W23-17 | 9-3 | .750 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| BOWLS | Thu Jan 2 | at#14Ole Miss | L20-52 | 9-4 | .692 | Vaught-Hemingway Stadium · Oxford, MS |
