| 1 | Sat Aug 31 | vs Kent State | W55-24 | 1-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 2 | Sat Sep 7 | at Cincinnati | W28-27 | 2-0 | 1.000 | Nippert Stadium · Cincinnati, OH |
| 3 | Sat Sep 14 | vs West Virginia | W38-34 | 3-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Sat Sep 21 | vs Youngstown St | W73-17 | 4-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sat Oct 5 | at UNC | W34-24 | 5-0 | 1.000 | Kenan Stadium · Chapel Hill, NC |
| 7 | Sat Oct 12 | vs California | W17-15 | 6-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 9 | Thu Oct 24 | vs Syracuse | W41-13 | 7-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sat Nov 2 | at #20SMU | L25-48 | 7-1 | .875 | Gerald J. Ford Stadium · Dallas, TX |
| 11 | Sat Nov 9 | vs Virginia | L19-24 | 7-2 | .778 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sat Nov 16 | vs #20Clemson | L20-24 | 7-3 | .700 | Acrisure Stadium · Pittsburgh, PA |
| 13 | Sat Nov 23 | at Louisville | L9-37 | 7-4 | .636 | Cardinal Stadium · Louisville, KY |
| 14 | Sat Nov 30 | at Boston College | L23-34 | 7-5 | .583 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| BOWLS | Thu Dec 26 | at Toledo | L46-48 (6OT) | 7-6 | .538 | Glass Bowl · Toledo, OH |
