| 1 | Sat Aug 30 | vs Duquesne | W61-9 | 1-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 2 | Sat Sep 6 | vsC Michigan | W45-17 | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sat Sep 13 | atWest Virginia | L24-31 (OT) | 2-1 | .667 | Milan Puskar Stadium · Morgantown, WV |
| 4 | Sat Sep 27 | vsLouisville | L27-34 | 2-2 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 5 | Sat Oct 4 | vsBoston College | W48-7 | 3-2 | .600 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sat Oct 11 | at#25Florida St | W34-31 | 4-2 | .667 | Doak Campbell Stadium · Tallahassee, FL |
| 7 | Sat Oct 18 | atSyracuse | W30-13 | 5-2 | .714 | JMA Wireless Dome · Syracuse, NY |
| 8 | Sat Oct 25 | vsNC State | W53-34 | 6-2 | .750 | Acrisure Stadium · Pittsburgh, PA |
| 9 | Sat Nov 1 | atStanford | W35-20 | 7-2 | .778 | Stanford Stadium · Stanford, CA |
| 10 | Sat Nov 15 | vs#9Notre Dame | L15-37 | 7-3 | .700 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sat Nov 22 | at#16Georgia Tech | W42-28 | 8-3 | .727 | Bobby Dodd Stadium · Atlanta, GA |
| 12 | Sat Nov 29 | vs#12Miami | L7-38 | 8-4 | .667 | Acrisure Stadium · Pittsburgh, PA |
