| 1 | Thu Sep 1 | vs West Virginia | W38-31 | 1-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 2 | Sat Sep 10 | vs#24Tennessee | L27-34 (OT) | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sat Sep 17 | atW Michigan | W34-13 | 2-1 | .667 | Waldo Stadium · Kalamazoo, MI |
| 4 | Sat Sep 24 | vsRhode Island | W45-24 | 3-1 | .750 | Acrisure Stadium · Pittsburgh, PA |
| 5 | Sat Oct 1 | vsGeorgia Tech | L21-26 | 3-2 | .600 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sat Oct 8 | vsVirginia Tech | W45-29 | 4-2 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Sat Oct 22 | atLouisville | L10-24 | 4-3 | .571 | Cardinal Stadium · Louisville, KY |
| 8 | Sat Oct 29 | at#21UNC | L24-42 | 4-4 | .500 | Kenan Stadium · Chapel Hill, NC |
| 9 | Sat Nov 5 | vs#20Syracuse | W19-9 | 5-4 | .556 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sat Nov 12 | atVirginia | W37-7 | 6-4 | .600 | Scott Stadium · Charlottesville, VA |
| 11 | Sat Nov 19 | vsDuke | W28-26 | 7-4 | .636 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sat Nov 26 | atMiami | W42-16 | 8-4 | .667 | Hard Rock Stadium · Miami Gardens, FL |
| BOWLS | Fri Dec 30 | atUCLA | W37-35 | 9-4 | .692 | Rose Bowl · Pasadena, CA |
